G1氨基丁酸A型受体相似蛋白2抗体

G1氨基丁酸A型受体相似蛋白2抗体英文名称  Anti-ATG8/GABARAPL2 

中文名称  G1氨基丁酸A型受体相似蛋白2抗体 

别    名  ATG 8; ATG8; FLC 3A; FLC3A; GABA(A) receptor associated protein like 2; Gamma aminobutyric acid receptor associated protein like 2; Ganglioside expression factor 2; GATE 16; GATE16; GEF 2; GEF2; General protein transport factor p16; MAP1 light chain 3 related protein. 

浓    度  1mg/1ml 

规 格  0.2ml/200μg    

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Chicken, Cow, Rabbit   

产品类型  一抗    

研究领域  肿瘤 细胞生物 免疫学 染色质和核信号 神经生物学 细胞凋亡  

蛋白分子量  predicted molecular weight: 14kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human GABARAPL2 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

G1氨基丁酸A型受体相似蛋白2抗体产品介绍 In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing (1). GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC (2,3). In addition to GABA receptors, several proteins have been identified as regulators of GABA function, including GAD65, GAD67, GABA transporters and GABARAP (GABAA receptor-associated protein) (4-6). GABARAP associates with GABAA Rg2 to link GABAA receptors to the cytoskeleton (6). The GABARAP protein sequence is similar to light chain-3 of microtubule-associated proteins (MAPs) suggesting that it may be a type of MAP or a component of a MAP complex (6). 

Function : Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.

Subcellular Location : Golgi apparatus.

Tissue Specificity : Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.

Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity : Belongs to the MAP1 LC3 family.

GABAA受体相关蛋白相似蛋白2；GABA受体A型相关蛋白样2