醛缩酶A抗体

醛缩酶A抗体英文名称  Anti-Aldolase A 

中文名称  醛缩酶A抗体 

别    名  ALDA; ALDOA; Aldolase A; Aldolase A fructose bisphosphatase; Aldolase A fructose bisphosphate; Fructose 1 6 bisphosphate triosephosphate lyase; Fructose bisphosphate aldolase A; Fructose bisphosphate aldolase; Lung cancer antigen NY LU 1; MGC10942; MGC17716; MGC17767; Muscle type aldolase; ALDOA_HUMAN. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep   

产品类型  一抗    

研究领域  免疫学 转录调节因子  

蛋白分子量  predicted molecular weight: 39kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human Aldolase A 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

醛缩酶A抗体产品介绍 Research areas:Cancer //Cancer Metabolism //Metabolic signaling pathway < 

Aldolase A (fructose bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3 phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants which encode the same protein. 

Cellular localization:Cytoplasmic 

Tissue Specificity:adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue.

Function : Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).

Subunit : Homotetramer. Interacts with SNX9 and WAS (By similarity).

DISEASE : Glycogen storage disease 12 (GSD12) [MIM:611881]: A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity : Belongs to the class I fructose-bisphosphate aldolase family.

Database links : UniProtKB/Swiss-Prot: P04075.2