血管紧张素Ⅱ-1型受体抗体

血管紧张素Ⅱ-1型受体抗体英文名称  Anti-AT1R/AGTR1 

中文名称  血管紧张素Ⅱ-1型受体抗体 

别    名  AG2S; Agtr 1; Agtr1; Agtr1a; AGTR1B; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; AT-1B; AT-1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; AGTR1_HUMAN; Type-1 angiotensin II receptor; Angiotensin II type-1 receptor. 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg 

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat, Cow, Sheep  

产品类型  一抗    

研究领域  心血管 细胞生物 细胞膜受体  

蛋白分子量  predicted molecular weight: 39kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human AT1R 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

血管紧张素Ⅱ-1型受体抗体产品介绍 Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq].

Function : Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subunit : Interacts with MAS1 (Probable). Interacts with ARRB1.

Subcellular Location : Cell membrane; Multi-pass membrane protein.

Tissue Specificity : Liver, lung, adrenal and adrenocortical adenomas.

Post-translational modifications : C-terminal Ser or Thr residues may be phosphorylated.

DISEASE : Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity : Belongs to the G-protein coupled receptor 1 family.

Database links : UniProtKB/Swiss-Prot: P30556.1 

AT1-受体：血管紧张素Ⅱ-1型受体抗体,主要用于心血管病方面的研究。