脂肪组织分化相关蛋白抗体

脂肪组织分化相关蛋白抗体英文名称  Anti-ADFP 

中文名称  脂肪组织分化相关蛋白抗体 

别    名  ADFP; Adipophilin; Adipose differentiation related protein; Adipose differentiation-related protein; Perilipin-2; PLIN2; PLIN2_HUMAN; adipophilin; Adipose differentiation related protein; ADRP; MGC10598 

浓    度  1mg/1ml 

规 格  0.1ml/100μg  0.2ml/200μg

抗体来源  Rabbit  

克隆类型  polyclonal 

交叉反应  Human, Mouse, Rat

产品类型  一抗    

研究领域  肿瘤 心血管 细胞生物 免疫学 信号转导 新陈代谢  

蛋白分子量  predicted molecular weight: 48kDa 

性    状  Lyophilized or Liquid 

免 疫 原  KLH conjugated synthetic peptide derived from human ADFP N-terminus 

亚    型  IgG 

纯化方法  affinity purified by Protein A 

储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide 

产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 

（石蜡切片需做抗原修复） 

 not yet tested in other applications.

 optimal dilutions/concentrations should be determined by the end user.  

保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

脂肪组织分化相关蛋白抗体产品介绍 Milk lipid globules from humans, cows and rats contain a protein identified as adipocyte differentiation-related protein (ADFP) associated with the globule surface membrane material. This protein, previously believed to be specific to adipocytes, was a major constituent of the globule surface and was present in a detergent-insoluble complex that contained stoichiometric amounts of butyrophilin and xanthine oxidase. ADFP (Adipophilin) occurs in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells. In tissues, however, expression of adipophilin is restricted to certain cell types, such as lactating mammary epithelial cells, adrenal cortex cells, Sertoli and Leydig cells of the male reproductive system, and steatosis or fatty change hepatocytes in alcoholic liver cirrhosis. ADFP may be a possible new marker for the identification of specialized differentiated cells containing lipid droplets and for diseases associated with fat-accumulating cells.

Function : May be involved in development and maintenance of adipose tissue (By similarity).

Subcellular Location : Membrane; Peripheral membrane protein.

Tissue Specificity : Milk lipid globules.

Post-translational modifications : Acylated; primarily with C14, C16 and C18 fatty acids.

Similarity : Belongs to the perilipin family.

Database links : UniProtKB/Swiss-Prot: Q99541.2

Adipophilin（ADFP）是一种脂滴周围主要的相关蛋白，它大量分布在脂质蓄积正常或不正常的细胞中，是脂质蓄积的一个特异性标记物。它在脂肪细胞分化早期就有很高的表达，但当脂肪细胞成熟后，它的表达就明显减少，故称；脂肪分化相关蛋白。