KW-2478|2mg|K1353-上海高创化学科技有限公司

SKU:K1353		M. Wt:574.66
Formula:C30H42N2O9		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:819812-04-9		Synonyms:N/A
Chemical NameN/A

Description	KW-2478
Targets	HSP90
IC50	3.8 nM
In vitro	KW-2478 reduces the level of phosphorylated Erk1/2. KW-2478 induces apoptosis by cleavage of PARP, a substrate of caspase-3 In U266 cells,. KW-2478 has Time dependency of antiproliferative activity, consecutive drug exposure for at least 12 hours is necessary to to exert potent antitumor activity.KW-2478 also shows potent growth inhibitory activity in primary CLL and NHL cells with EC50 of 40-170 nM and 200-400 nM, respectively.
In vivo	KW-2478 suppresses tumor growth and induces the degradation of client proteins in tumors in NCI-H929 s.c. inoculated model at doses of 100 mg/kg or more.
Clinical Trials	N/A
Features	N/A

Description

KW-2478

Targets

HSP90

IC50

3.8 nM

In vitro

KW-2478 reduces the level of phosphorylated Erk1/2. KW-2478 induces apoptosis by cleavage of PARP, a substrate of caspase-3 In U266 cells,. KW-2478 has Time dependency of antiproliferative activity, consecutive drug exposure for at least 12 hours is necessary to to exert potent antitumor activity.KW-2478 also shows potent growth inhibitory activity in primary CLL and NHL cells with EC50 of 40-170 nM and 200-400 nM, respectively.

In vivo

KW-2478 suppresses tumor growth and induces the degradation of client proteins in tumors in NCI-H929 s.c. inoculated model at doses of 100 mg/kg or more.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

KW-2478由上海高创化学科技有限公司为您提供，货号K1353，规格：2mg，CAS号：819812-04-9，如您想了解更多关于KW-2478价格、KW-2478结构式、批发、用途等信息，欢迎咨询。除供应KW-2478外，还可为您提供含铁牛血清（新西兰）、重组人卵泡抑素/Human FST His、特级新生牛血清（无噬菌体低内毒素）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。