CHIR-124|2mg|K1352-上海高创化学科技有限公司

SKU:K1352		M. Wt:419.91
Formula:C23H22ClN5O		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:405168-58-3		Synonyms:N/A
Chemical NameN/A

Description	CHIR-124
Targets	Chk1
IC50	0.3 nM
In vitro	CHIR-124 is a quinolone-based small molecule that is structurally unrelated to other known inhibitors of Chk1. CHIR-124 interacts synergistically with topoisomerase poisons (e.g., Camptothecin or SN-38) in causing growth inhibition in a variety of cancer cell lines, including breast carcinoma (MDA-MB-231 and MDA-MB-435) and colon carcinoma (SW-620 and Colo205), all of which contains the mutant p53 gene.
In vivo	CHIR-124 potentiates the growth inhibitory effects of Irinotecan by abrogating the G2-M checkpoint and increasing tumor apoptosis in an orthotopic breast cancer xenograft model.
Clinical Trials	N/A
Features	N/A

Description

CHIR-124

Targets

Chk1

IC50

0.3 nM

In vitro

CHIR-124 is a quinolone-based small molecule that is structurally unrelated to other known inhibitors of Chk1. CHIR-124 interacts synergistically with topoisomerase poisons (e.g., Camptothecin or SN-38) in causing growth inhibition in a variety of cancer cell lines, including breast carcinoma (MDA-MB-231 and MDA-MB-435) and colon carcinoma (SW-620 and Colo205), all of which contains the mutant p53 gene.

In vivo

CHIR-124 potentiates the growth inhibitory effects of Irinotecan by abrogating the G2-M checkpoint and increasing tumor apoptosis in an orthotopic breast cancer xenograft model.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

CHIR-124由上海高创化学科技有限公司为您提供，货号K1352，规格：2mg，CAS号：405168-58-3，如您想了解更多关于CHIR-124价格、CHIR-124结构式、批发、用途等信息，欢迎咨询。除供应CHIR-124外，还可为您提供大鼠胆囊收缩素/缩胆囊素八肽(CCK-8)ELISA Kit、热灭活胎牛血清（澳大利亚）、重组大鼠抵抗素(Rat Resistin)等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。