AMG458|2mg|K1336-上海高创化学科技有限公司

SKU:K1336		M. Wt:539.58
Formula:C30H29N5O5		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:913376-83-7		Synonyms:N/A
Chemical NameN/A

Description	AMG458
Targets	human c-Met	mouse c-Met
IC50	1.2 nM(Ki)	2.0 nM(Ki)
In vitro	AMG 458 can potently inhibit human c-Met and mouse c-Met with Ki of 1.2 nM or 2.0 nM. AMG-458 enhances radiosensitivity in H441 but not in A549. A549 expresses low levels of c-Met, which were phosphorylated only in the presence of exogenous hepatocyte growth factor. The combination of radiation therapy and AMG-458 treatment synergistically increase apoptosis in the H441 cell line but not in A549. Radiation therapy, AMG-458, and combination treatment were found to reduce p-Akt and p-Erk levels in H441 but not in A549. H441 became less sensitive to AMG-458 after small interfering RNA knockdown of c-Met; there was no change in A549. After overexpression of c-Met, A549 became more sensitive, while H441 became less sensitive to AMG-458. AMG-458 is more effective in cells that expressed higher levels of c-Met/p-Met.[1]
In vivo	N/A
Clinical Trials	N/A
Features	N/A

Description

AMG458

Targets

human c-Met

mouse c-Met

IC50

1.2 nM(Ki)

2.0 nM(Ki)

In vitro

AMG 458 can potently inhibit human c-Met and mouse c-Met with Ki of 1.2 nM or 2.0 nM. AMG-458 enhances radiosensitivity in H441 but not in A549. A549 expresses low levels of c-Met, which were phosphorylated only in the presence of exogenous hepatocyte growth factor. The combination of radiation therapy and AMG-458 treatment synergistically increase apoptosis in the H441 cell line but not in A549. Radiation therapy, AMG-458, and combination treatment were found to reduce p-Akt and p-Erk levels in H441 but not in A549. H441 became less sensitive to AMG-458 after small interfering RNA knockdown of c-Met; there was no change in A549. After overexpression of c-Met, A549 became more sensitive, while H441 became less sensitive to AMG-458. AMG-458 is more effective in cells that expressed higher levels of c-Met/p-Met.[1]

In vivo

N/A

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

AMG458由上海高创化学科技有限公司为您提供，货号K1336，规格：2mg，CAS号：913376-83-7，如您想了解更多关于AMG458价格、AMG458结构式、批发、用途等信息，欢迎咨询。除供应AMG458外，还可为您提供重组人半乳糖凝集素16/LGALS16 Human、含铁牛血清（新西兰）、重组人β防御素118/DEFB118 Human等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。