PHA-767491|10mg|K1331-上海高创化学科技有限公司

SKU:K1331		M. Wt:213.24
Formula:C12H11N3O		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:845714-00-3		Synonyms:N/A
Chemical NameN/A

Description	PHA-767491
Targets	Cdc7
IC50	0.6 nM(EC50)
In vitro	PHA-767491 is a potent Cdc7 inhibitor. PHA-767491 is the first molecule that directly affects the mechanisms controlling initiation as opposed to elongation in DNA replication. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. PHA-767491 prevents the activation of replication origins but does not impede replication fork progression, and it does not trigger a sustained DNA damage response. PHA-767491 induced apoptosis in all CLL samples tested with an average EC50 of 0.6 uM. PHA-767491 activates the intrinsic apoptotic pathway in resting CLL cells. Exposure of CLL cells to 1 uM PHA-767491 induced Bax activation occurs upstream of caspase activation. PHA-767491 induces downregulation of Mcl-1 protein in a caspase-independent manner. And DNA synthesis and Cdc7 activity of IL-4 and CD154-stimulated CLL cells can be inhibited by PHA-767491.
In vivo	In preclinical cancer models, PHA-767491 shows inhibition to multiple cancer cell types and tumor growth.
Clinical Trials	N/A
Features	N/A

Description

PHA-767491

Targets

Cdc7

IC50

0.6 nM(EC50)

In vitro

PHA-767491 is a potent Cdc7 inhibitor. PHA-767491 is the first molecule that directly affects the mechanisms controlling initiation as opposed to elongation in DNA replication. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites. PHA-767491 prevents the activation of replication origins but does not impede replication fork progression, and it does not trigger a sustained DNA damage response. PHA-767491 induced apoptosis in all CLL samples tested with an average EC50 of 0.6 uM. PHA-767491 activates the intrinsic apoptotic pathway in resting CLL cells. Exposure of CLL cells to 1 uM PHA-767491 induced Bax activation occurs upstream of caspase activation. PHA-767491 induces downregulation of Mcl-1 protein in a caspase-independent manner. And DNA synthesis and Cdc7 activity of IL-4 and CD154-stimulated CLL cells can be inhibited by PHA-767491.

In vivo

In preclinical cancer models, PHA-767491 shows inhibition to multiple cancer cell types and tumor growth.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

PHA-767491由上海高创化学科技有限公司为您提供，货号K1331，规格：10mg，CAS号：845714-00-3，如您想了解更多关于PHA-767491价格、PHA-767491结构式、批发、用途等信息，欢迎咨询。除供应PHA-767491外，还可为您提供人瘦素(LEP)ELISA Kit、含铁牛血清（新西兰）、重组人半乳糖凝集素3/Human LGALS3 His等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。