AZ 3146|5mg|K1330-上海高创化学科技有限公司

SKU:K1330		M. Wt:452.55
Formula:C24H32N6O3		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:1124329-14-1		Synonyms:N/A
Chemical NameN/A

Description	AZ 3146
Targets	MSP1
IC50	35 nM
In vitro	AZ3146 inhibits human Mps1Cat with an IC50 of 35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells. AZ3146 is a reasonably potent and selective Mps1 inhibitor. AZ3146 overrides the spindle checkpoint. HeLa cells treated with nocodazole and 2 ?M AZ3146 only delayed mitosis briefly and then rereplicated their genomes. During an otherwise unperturbed mitosis, AZ3146 reduced the time to complete mitosis from 90 min in controls to 32 min. During mitosis, Mps1 activity is required continuously to recruit Mad2 to kinetochore-bound Mad1, but AZ3146 can abolish Mad2 localization. And inhibition of Mps1 by AZ3146 can increase its abundance at kinetochores.
In vivo
Clinical Trials	N/A
Features	N/A

Description

AZ 3146

Targets

MSP1

IC50

35 nM

In vitro

AZ3146 inhibits human Mps1Cat with an IC50 of 35 nM. AZ3146 also efficiently inhibited autophosphorylation of full-length Mps1 immunoprecipitated from human cells. AZ3146 is a reasonably potent and selective Mps1 inhibitor. AZ3146 overrides the spindle checkpoint. HeLa cells treated with nocodazole and 2 ?M AZ3146 only delayed mitosis briefly and then rereplicated their genomes. During an otherwise unperturbed mitosis, AZ3146 reduced the time to complete mitosis from 90 min in controls to 32 min. During mitosis, Mps1 activity is required continuously to recruit Mad2 to kinetochore-bound Mad1, but AZ3146 can abolish Mad2 localization. And inhibition of Mps1 by AZ3146 can increase its abundance at kinetochores.

In vivo

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

AZ 3146由上海高创化学科技有限公司为您提供，货号K1330，规格：5mg，CAS号：1124329-14-1，如您想了解更多关于AZ 3146价格、AZ 3146结构式、批发、用途等信息，欢迎咨询。除供应AZ 3146外，还可为您提供大鼠酸性磷酸酶(ACP)ELISA Kit、Gibco马血清（新西兰）、热灭活马血清（新西兰）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。