TAK-875|2mg|K1329-上海高创化学科技有限公司

SKU:K1329		M. Wt:533.63
Formula:C29H32O7S.1/2H2O		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:1374598-80-7		Synonyms:N/A
Chemical NameN/A

Description	TAK-875
Targets	GPR40
IC50	14 nM(EC50)
In vitro	TAK-875 is a selective G-protein-coupled receptor 40 agonist in development for the treatment of type 2 diabetes mellitus. In rat insulinoma INS-1 833/15 cells, TAK-875 increased intracellular inositol monophosphate and calcium concentration, consistent with activation of the Gqalpha signaling pathway. The insulinotropic action of TAK-875 (10 uM) in INS-1 833/15 and primary rat islets was glucose-dependent.
In vivo	In an oral glucose tolerance test in type 2 diabetic N-STZ-1.5 rats, TAK-875 (1-10 mg/kg p.o.) showed a clear improvement in glucose tolerance and augmented insulin secretion. TAK-875 (10 mg/kg, p.o.) significantly augmented plasma insulin levels and reduced fasting hyperglycemia in male Zucker diabetic fatty rats, whereas in fasted normal Sprague-Dawley rats, TAK-875 neither enhanced insulin secretion nor caused hypoglycemia even at 30 mg/kg.
Clinical Trials	N/A
Features	N/A

Description

TAK-875

Targets

GPR40

IC50

14 nM(EC50)

In vitro

TAK-875 is a selective G-protein-coupled receptor 40 agonist in development for the treatment of type 2 diabetes mellitus. In rat insulinoma INS-1 833/15 cells, TAK-875 increased intracellular inositol monophosphate and calcium concentration, consistent with activation of the Gqalpha signaling pathway. The insulinotropic action of TAK-875 (10 uM) in INS-1 833/15 and primary rat islets was glucose-dependent.

In vivo

In an oral glucose tolerance test in type 2 diabetic N-STZ-1.5 rats, TAK-875 (1-10 mg/kg p.o.) showed a clear improvement in glucose tolerance and augmented insulin secretion. TAK-875 (10 mg/kg, p.o.) significantly augmented plasma insulin levels and reduced fasting hyperglycemia in male Zucker diabetic fatty rats, whereas in fasted normal Sprague-Dawley rats, TAK-875 neither enhanced insulin secretion nor caused hypoglycemia even at 30 mg/kg.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

TAK-875由上海高创化学科技有限公司为您提供，货号K1329，规格：2mg，CAS号：1374598-80-7，如您想了解更多关于TAK-875价格、TAK-875结构式、批发、用途等信息，欢迎咨询。除供应TAK-875外，还可为您提供国产特级胎牛血清（无噬菌体低内毒素）、重组大鼠抵抗素(Rat Resistin)、大鼠胆囊收缩素/缩胆囊素八肽(CCK-8)ELISA Kit等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。