GW3965 HCl|2mg|K1327-上海高创化学科技有限公司

SKU:K1327		M. Wt:618.51
Formula:C33H31ClF3NO3.HCl		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:405911-17-3		Synonyms:N/A
Chemical NameN/A

Description	GW3965 HCl
Targets	LXRalpha/SRC1?LiSA	LXRalpha-GAL4
IC50	125 nM(EC50)	190 nM(EC50)
In vitro	GW3965 can inhibit liver X receptor (LXR), which can activate genes that regulate lipid and cholesterol metabolism. Treatment of primary human hepatocytes with GW3965 results in reduced output of bile acids and very low density lipoprotein triglycerides and induced expression of adipose differentiation-related protein accompanied by increased lipid storage. In pentobarbital-anesthetized male Sprague-Dawley rats, after oral administration of GW3965 (10 mg kg(-1), q.d.) , GW3965 dosing blunted the vasopressor effect of Ang II, which was significantly different with the 0.3 and 3 microg kg(-1) doses. GW3965 decreased Ang II-mediated vasopressor responses coincident with a trend toward reduced ATR gene expression, suggesting that LXR agonists could affect vascular reactivity. GW3965 could modulate the inflammatory status of human pancreatic islets. Treatment of LPS-stimulated human islets with the synthetic LXR agonist GW3965 (1 micromol/l) for 24 h reduced mRNA and protein levels of selected pro-inflammatory cytokines (IL-8, monocyte chemotactic protein-1 and tissue factor). Even liver X receptor (LXR) agonism has previously been shown to increase insulin release from pancreatic islets and reduce inflammation in leucocytes, GW3965,as a agonist of agonist, had no adverse effect on insulin secretion, islet viability or apoptosis.
In vivo	GW3965 can induce transcription of several genes including ABCA1 and apoE, and reduce Abeta levels and improve cognition in AD mice. Treatment of APP/PS1 mice with GW3965 increased ABCA1 and apoE protein levels.At 33 mg/kg/day, GW3965 was also associated with a trend toward redistribution of Abeta to the carbonate-soluble pool independent of ABCA1.
Clinical Trials	N/A
Features	N/A

Description

GW3965 HCl

Targets

LXRalpha/SRC1?LiSA

LXRalpha-GAL4

IC50

125 nM(EC50)

190 nM(EC50)

In vitro

GW3965 can inhibit liver X receptor (LXR), which can activate genes that regulate lipid and cholesterol metabolism. Treatment of primary human hepatocytes with GW3965 results in reduced output of bile acids and very low density lipoprotein triglycerides and induced expression of adipose differentiation-related protein accompanied by increased lipid storage. In pentobarbital-anesthetized male Sprague-Dawley rats, after oral administration of GW3965 (10 mg kg(-1), q.d.) , GW3965 dosing blunted the vasopressor effect of Ang II, which was significantly different with the 0.3 and 3 microg kg(-1) doses. GW3965 decreased Ang II-mediated vasopressor responses coincident with a trend toward reduced ATR gene expression, suggesting that LXR agonists could affect vascular reactivity. GW3965 could modulate the inflammatory status of human pancreatic islets. Treatment of LPS-stimulated human islets with the synthetic LXR agonist GW3965 (1 micromol/l) for 24 h reduced mRNA and protein levels of selected pro-inflammatory cytokines (IL-8, monocyte chemotactic protein-1 and tissue factor). Even liver X receptor (LXR) agonism has previously been shown to increase insulin release from pancreatic islets and reduce inflammation in leucocytes, GW3965,as a agonist of agonist, had no adverse effect on insulin secretion, islet viability or apoptosis.

In vivo

GW3965 can induce transcription of several genes including ABCA1 and apoE, and reduce Abeta levels and improve cognition in AD mice. Treatment of APP/PS1 mice with GW3965 increased ABCA1 and apoE protein levels.At 33 mg/kg/day, GW3965 was also associated with a trend toward redistribution of Abeta to the carbonate-soluble pool independent of ABCA1.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

GW3965 HCl由上海高创化学科技有限公司为您提供，货号K1327，规格：2mg，CAS号：405911-17-3，如您想了解更多关于GW3965 HCl价格、GW3965 HCl结构式、批发、用途等信息，欢迎咨询。除供应GW3965 HCl外，还可为您提供重组人半乳糖凝集素3/Human LGALS3 His、重组人半乳糖凝集素8/Human LGALS8 His、重组大鼠抵抗素(Rat Resistin)等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。