Mubritinib(TAK 165)|10mg|K1324-上海高创化学科技有限公司

SKU:K1324		M. Wt:468.47
Formula:C25H23F3N4O2		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:366017-09-6		Synonyms:TAK 165, TAK165
Chemical NameN/A

Description	Mubritinib(TAK 165)
Targets	ErbB2
IC50	6 nM
In vitro	TAK-165 can inhibit HT1376, UMUC3, T24 (bladder), ACHN (kidney), DU145, LNCaP, LN-REC4 (prostate) cell lines, which are observed HER2 expression, with IC50 from 0.09 to greater than 25 micromol/L. The prostate cancer cell lines are all sensitive to mubritinib (TAK 165).Mubritinib (TAK 165) can inhibit prostate cancer cell lines with IC50 from 0.053to 4.62 micromol/L.
In vivo	In the xenograft model, treatment with TAK-165 significantly inhibited growth of UMUC-3, ACHN, and LN-REC4. The antitumor effect (T/C [%]=growth of TAK-165 treated tumor/average growth of control tumorx100) after 14 days treatment were 22.9%, 26.0%, and 26.5% in UMUC3, ACHN and LN-REC4, respectively.
Clinical Trials	N/A
Features	N/A

Description

Mubritinib(TAK 165)

Targets

ErbB2

IC50

6 nM

In vitro

TAK-165 can inhibit HT1376, UMUC3, T24 (bladder), ACHN (kidney), DU145, LNCaP, LN-REC4 (prostate) cell lines, which are observed HER2 expression, with IC50 from 0.09 to greater than 25 micromol/L. The prostate cancer cell lines are all sensitive to mubritinib (TAK 165).Mubritinib (TAK 165) can inhibit prostate cancer cell lines with IC50 from 0.053to 4.62 micromol/L.

In vivo

In the xenograft model, treatment with TAK-165 significantly inhibited growth of UMUC-3, ACHN, and LN-REC4. The antitumor effect (T/C [%]=growth of TAK-165 treated tumor/average growth of control tumorx100) after 14 days treatment were 22.9%, 26.0%, and 26.5% in UMUC3, ACHN and LN-REC4, respectively.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

Mubritinib(TAK 165)由上海高创化学科技有限公司为您提供，货号K1324，规格：10mg，CAS号：366017-09-6，如您想了解更多关于Mubritinib(TAK 165)价格、Mubritinib(TAK 165)结构式、批发、用途等信息，欢迎咨询。除供应Mubritinib(TAK 165)外，还可为您提供国产特级胎牛血清（无噬菌体低内毒素）、大鼠胆囊收缩素/缩胆囊素八肽(CCK-8)ELISA Kit、超级新生牛血清（无噬菌体低内毒素）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。