AT13387|2mg|K1318-上海高创化学科技有限公司

SKU:K1318		M. Wt:409.52
Formula:C24H31N3O3		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:912999-49-6		Synonyms:N/A
Chemical NameN/A

Description	AT13387
Targets	HSP90
IC50	18 nM
In vitro	AT13387 is a novel, high-affinity, and non-geldanamycin inhibitor of the molecular chaperone Hsp90(heat-shock protein 90) by fragment based drug design. AT13387 can potently inhibit Hsp90 with IC50 of 18 nM in A375 cells. In vitro, AT13387 shows activity against a wide array of tumor cell lines, including lung cancer cell lines. AT13387 showed a median EC50 value of 41 nM against the PPTP and exhibited activity consistent with a cytotoxic effect.AT13387 can induce the degradation of specific HSP90 client proteins for up to 7 days in tumor cell lines in vitro. AT13387 caninhibit the proliferation of imatinib-sensitive (GIST882, GIST-T1) and -resistant (GIST430, GIST48) cell lines, including those resistant to the geldanamycin analogue HSP90 inhibitor, 17-AAG.
In vivo	In vivo, administered orally twice weekly, AT13387 induced significant differences in EFS distribution compared to controls in 17% evaluable solid tumor xenografts, but in none of the ALL xenografts. Once weekly administration in human lung carcinoma xenografts, treatment with AT13387 also can induce a long duration of client protein knockdown and suppression of phospho-signaling. Antitumor activity of AT13387 was showed in both the imatinib-sensitive, GIST-PSW, xenograft model and a newly characterized imatinib-resistant, GIST430, xenograft model.
Clinical Trials	N/A
Features	N/A

Description

AT13387

Targets

HSP90

IC50

18 nM

In vitro

AT13387 is a novel, high-affinity, and non-geldanamycin inhibitor of the molecular chaperone Hsp90(heat-shock protein 90) by fragment based drug design. AT13387 can potently inhibit Hsp90 with IC50 of 18 nM in A375 cells. In vitro, AT13387 shows activity against a wide array of tumor cell lines, including lung cancer cell lines. AT13387 showed a median EC50 value of 41 nM against the PPTP and exhibited activity consistent with a cytotoxic effect.AT13387 can induce the degradation of specific HSP90 client proteins for up to 7 days in tumor cell lines in vitro. AT13387 caninhibit the proliferation of imatinib-sensitive (GIST882, GIST-T1) and -resistant (GIST430, GIST48) cell lines, including those resistant to the geldanamycin analogue HSP90 inhibitor, 17-AAG.

In vivo

In vivo, administered orally twice weekly, AT13387 induced significant differences in EFS distribution compared to controls in 17% evaluable solid tumor xenografts, but in none of the ALL xenografts. Once weekly administration in human lung carcinoma xenografts, treatment with AT13387 also can induce a long duration of client protein knockdown and suppression of phospho-signaling. Antitumor activity of AT13387 was showed in both the imatinib-sensitive, GIST-PSW, xenograft model and a newly characterized imatinib-resistant, GIST430, xenograft model.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

AT13387由上海高创化学科技有限公司为您提供，货号K1318，规格：2mg，CAS号：912999-49-6，如您想了解更多关于AT13387价格、AT13387结构式、批发、用途等信息，欢迎咨询。除供应AT13387外，还可为您提供热灭活胎牛血清、人瘦素(LEP)ELISA Kit、大鼠酸性磷酸酶(ACP)ELISA Kit等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。