STF-62247|5mg|K1317-上海高创化学科技有限公司

SKU:K1317		M. Wt:267.35
Formula:C15H13N3S		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:315702-99-9		Synonyms:N/A
Chemical NameN/A

Description	STF-62247
Targets
IC50	N/A
In vitro	STF-62247 specifically induces autophagic cell death in cells that have lost VHL, an essential mutation in the development of RCC. Treatment with STF-62247 did not alter cell cycle progression but when combined with radiation increased cell killing under oxic and hypoxic/physiological conditions. The cytotoxicity of STF-62247 is due to dysregulated autophagy. The reduction of protein levels of essential autophagy pathway components such as Atg5, Atg7 and Atg9 reduces sensitivity of VHL-deficient cells to killing by STF-62247. Loss of proteins involved in Golgi trafficking sensitized RCC with wild-type VHL to killing by STF-62247.
In vivo	In vivo mouse model, STF-62247 at a dose of 8 mg/kg byby intraperitoneal injection significantly reduces tumor growth of VHL-deficient SN12C tumor cells.
Clinical Trials	N/A
Features	N/A

Description

STF-62247

Targets

IC50

N/A

In vitro

STF-62247 specifically induces autophagic cell death in cells that have lost VHL, an essential mutation in the development of RCC. Treatment with STF-62247 did not alter cell cycle progression but when combined with radiation increased cell killing under oxic and hypoxic/physiological conditions. The cytotoxicity of STF-62247 is due to dysregulated autophagy. The reduction of protein levels of essential autophagy pathway components such as Atg5, Atg7 and Atg9 reduces sensitivity of VHL-deficient cells to killing by STF-62247. Loss of proteins involved in Golgi trafficking sensitized RCC with wild-type VHL to killing by STF-62247.

In vivo

In vivo mouse model, STF-62247 at a dose of 8 mg/kg byby intraperitoneal injection significantly reduces tumor growth of VHL-deficient SN12C tumor cells.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

STF-62247由上海高创化学科技有限公司为您提供，货号K1317，规格：5mg，CAS号：315702-99-9，如您想了解更多关于STF-62247价格、STF-62247结构式、批发、用途等信息，欢迎咨询。除供应STF-62247外，还可为您提供热灭新生牛血清（新西兰）、重组人心肌营养素1/CTF1 Human、超级新生牛血清（无支原体）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。