SNX-2112|2mg|K1314-上海高创化学科技有限公司

SKU:K1314		M. Wt:464.48
Formula:C23H27F3N4O3		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:908112-43-6, 945626-71-1		Synonyms:N/A
Chemical NameN/A

Description	SNX-2112
Targets	HSP90-alpha	HSP90-beta
IC50	30 nM(Ka)	30 nM(Ka)
In vitro	As a selective and ATP-compeitive inhibitor, SNX-2112 can inhibit HSP90alpha and HSP90beta with Ka of 30 nM and 30 nM by competitively binding to the N-terminal adenosine triphosphate binding site of Hsp90. SNX-2112 inhibits cell proliferatin of BT474, SKBR-3, SKOV-3, MDA-468, MCF-7 and H1650 cancer cells with IC50 from 10 to 50 nM.SNX-2112 also can induces cell apoptosis by inducing caspase-8, -9, -3, and poly (ADPribose) polymerase cleavage. ERK and Akt can be activated by SNX-2112. By abrogating eNOS/Akt pathway, SNX-2112 inhibits tube formation in human umbilical vein endothelial cells.
In vivo	In a xenograft murine model, SNX-2112 can inhibits MM cell growth and prolongs survival.
Clinical Trials	N/A
Features	N/A

Description

SNX-2112

Targets

HSP90-alpha

HSP90-beta

IC50

30 nM(Ka)

In vitro

As a selective and ATP-compeitive inhibitor, SNX-2112 can inhibit HSP90alpha and HSP90beta with Ka of 30 nM and 30 nM by competitively binding to the N-terminal adenosine triphosphate binding site of Hsp90. SNX-2112 inhibits cell proliferatin of BT474, SKBR-3, SKOV-3, MDA-468, MCF-7 and H1650 cancer cells with IC50 from 10 to 50 nM.SNX-2112 also can induces cell apoptosis by inducing caspase-8, -9, -3, and poly (ADPribose) polymerase cleavage. ERK and Akt can be activated by SNX-2112. By abrogating eNOS/Akt pathway, SNX-2112 inhibits tube formation in human umbilical vein endothelial cells.

In vivo

In a xenograft murine model, SNX-2112 can inhibits MM cell growth and prolongs survival.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

SNX-2112由上海高创化学科技有限公司为您提供，货号K1314，规格：2mg，CAS号：908112-43-6，如您想了解更多关于SNX-2112价格、SNX-2112结构式、批发、用途等信息，欢迎咨询。除供应SNX-2112外，还可为您提供超级新生牛血清（无支原体）、热灭活马血清（新西兰）、重组人卵泡抑素/Human FST His等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。