Isoliquiritigenin|2mg|K1313-上海高创化学科技有限公司

SKU:K1313		M. Wt:256.25
Formula:C15H12O4		Solubility:N/A
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:961-29-5		Synonyms:N/A
Chemical NameN/A

Description	Isoliquiritigenin (ISL) is a chalcone compound with valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer and anti-allergic activities.Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABA receptors and shows hypnotic effects.
Targets
IC50	N/A
In vitro	Isoliquiritigenin (ISL) is a chalcone compound with valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer and anti-allergic activities.Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABA A receptors and shows hypnotic effects. ISL also can suppress HIF-1alpha level, VEGF expression and secretion, cell migration and to decrease the expression and secretion of MMP-9/-2. ISL inhibited the proliferation of U87 cells in a time-dependent and dose-dependent manner.ISL induced the apoptosis of the U87 cells and blocked cell cycle progression at the S and G2/M phases. ISL induced the apoptosis of the U87 cells in a caspase-dependent manner. ISL upregulated p21/WAF1 and p27. Cell cycle arrest and the caspase-mediated apoptosis pathway may participate in the antiproliferative activity of ISL in U87 cells by regulating the expression of ISL. There is a strong dose-response relationship between ISL exposure and the characteristics of B16F0 differentiation in terms of morphology changes and melanogenesis. Isoliquiritigenin also can inhibit one of the most drug-metabolizing enzymes (DMEs) UDP-glucuronosyltransferase (UGT). 100uM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%. Low concentration of ISL may have therapeutic potential in the treatment of aggressive breast carcinoma and other neoplasms.
In vivo	The tumorigenicity of ISL-treated cells was limited significantly in an animal model assay in vivo respectively.
Clinical Trials	N/A
Features	N/A

Description

Targets

IC50

N/A

In vitro

Isoliquiritigenin (ISL) is a chalcone compound with valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer and anti-allergic activities.Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABA A receptors and shows hypnotic effects. ISL also can suppress HIF-1alpha level, VEGF expression and secretion, cell migration and to decrease the expression and secretion of MMP-9/-2. ISL inhibited the proliferation of U87 cells in a time-dependent and dose-dependent manner.ISL induced the apoptosis of the U87 cells and blocked cell cycle progression at the S and G2/M phases. ISL induced the apoptosis of the U87 cells in a caspase-dependent manner. ISL upregulated p21/WAF1 and p27. Cell cycle arrest and the caspase-mediated apoptosis pathway may participate in the antiproliferative activity of ISL in U87 cells by regulating the expression of ISL. There is a strong dose-response relationship between ISL exposure and the characteristics of B16F0 differentiation in terms of morphology changes and melanogenesis. Isoliquiritigenin also can inhibit one of the most drug-metabolizing enzymes (DMEs) UDP-glucuronosyltransferase (UGT). 100uM of isoliquiritigenin inhibited the activity of UGT1A1, UGT1A3, UGT1A6, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 by 95.2%, 76.1%, 78.9%, 87.2%, 67.2%, 94.8%, and 91.7%. Low concentration of ISL may have therapeutic potential in the treatment of aggressive breast carcinoma and other neoplasms.

In vivo

The tumorigenicity of ISL-treated cells was limited significantly in an animal model assay in vivo respectively.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

Isoliquiritigenin由上海高创化学科技有限公司为您提供，货号K1313，规格：2mg，CAS号：961-29-5，如您想了解更多关于Isoliquiritigenin价格、Isoliquiritigenin结构式、批发、用途等信息，欢迎咨询。除供应Isoliquiritigenin外，还可为您提供热灭活胎牛血清（澳大利亚）、重组人半乳糖凝集素3/Human LGALS3 His、兔子血清等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。