Lapatinib|2mg|K1290-上海高创化学科技有限公司

SKU:K1290		M. Wt:581.06
Formula:C29H26ClFN4O4S		Solubility:DMSO 100 mg/mL, Water <1 mg/mL, Ethanol <1 mg/mL
Purity:>99%		Storage:2 years -20°C Powder
CAS No.:231277-92-2		Synonyms:GW572016
Chemical NameN-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-6-(5-((2-(methylsulfonyl)ethylamino)methyl)furan-2-yl)quinazolin-4-amine,di4-methylbenzenesulfonate

Description	Lapatinib
Targets	EGFR	ErbB2
IC50	10.8 nM	9.2 nM
In vitro	Lapatinib can inihbit Epidermal growth factor receptor (erbB1) with IC50 of 2.9 nM.[1] Lapatinib also inhibit receptor protein-tyrosine kinase(erbB-2) with IC50 around 3 nM.[1] Overexpression of ABC subfamily B member 1 (ABCB1) and ABC subfamily G member 2 (ABCG2) transporters would result in tumor multidrug resistance (MDR). Lapatinib significantly enhanced the sensitivity to ABCB1 or ABCG2 substrates in cells by stimulating the ATPase activity of both ABCB1 and ABCG2. And lapatinib reverses ABCB1- and ABCG2-mediated MDR by directly inhibiting their transport function so that lapatinib (Tykerb, GW572016) may combinate with other inhibitors to block proliferation of cancer cells and get better results. Lapatinib can inhibit SK-OV-3, an Ovarian carcinoma cell line which overexpress HER2, with IC50 from 3 to 4.5 nM.
In vivo	N/A
Clinical Trials	N/A
Features	N/A

Description

Lapatinib

Targets

EGFR

ErbB2

IC50

10.8 nM

9.2 nM

In vitro

Lapatinib can inihbit Epidermal growth factor receptor (erbB1) with IC50 of 2.9 nM.[1] Lapatinib also inhibit receptor protein-tyrosine kinase(erbB-2) with IC50 around 3 nM.[1] Overexpression of ABC subfamily B member 1 (ABCB1) and ABC subfamily G member 2 (ABCG2) transporters would result in tumor multidrug resistance (MDR). Lapatinib significantly enhanced the sensitivity to ABCB1 or ABCG2 substrates in cells by stimulating the ATPase activity of both ABCB1 and ABCG2. And lapatinib reverses ABCB1- and ABCG2-mediated MDR by directly inhibiting their transport function so that lapatinib (Tykerb, GW572016) may combinate with other inhibitors to block proliferation of cancer cells and get better results. Lapatinib can inhibit SK-OV-3, an Ovarian carcinoma cell line which overexpress HER2, with IC50 from 3 to 4.5 nM.

In vivo

N/A

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

Lapatinib由上海高创化学科技有限公司为您提供，货号K1290，规格：2mg，CAS号：231277-92-2，如您想了解更多关于Lapatinib价格、Lapatinib结构式、批发、用途等信息，欢迎咨询。除供应Lapatinib外，还可为您提供重组人肌球蛋白轻链2(Recombinant Human MYL2)、Gibco马血清（新西兰）、国产特级胎牛血清（无噬菌体低内毒素）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。