ZM306416|2mg|K1288-上海高创化学科技有限公司

SKU:K1288		M. Wt:333.74
Formula:C16H13ClFN3O2		Solubility:DMSO 67 mg/mL, Water <1 mg/mL, Ethanol <1 mg/mL
Purity:99%		Storage:2 years -20°C Powder
CAS No.:690206-97-4		Synonyms:N/A
Chemical NameN/A

Description	ZM-306416 is a VEGFR antagonist and ZM-306416 can inhibit VEGFR with IC50 of 0.67 uM.
Targets	VEGFR
IC50	0.67 uM
In vitro	ZM-306416 is a VEGFR antagonist and ZM-306416 can inhibit VEGFR with IC50 of 0.67 uM. Sharing the 4-anilinoquinazoline scaffold common among EGFR kinase inhibitors such as erlotinib, gefitinib and lapatinib棓 ZM-306416 also shows potent inhibition to EGFR. ZM-306416 can potently inhibit the EGFR kinase with an IC50 value lower than 10 nM. ZM-306416 exhibits inhibitory activity across all three kinases of the panel, yielding IC50 values of 0.33 uM for SRC, 0.33 uM for VEGFR1, and 1.3 uM for ABL kinases. ZM-306416 can also induces selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 with IC50 of 0.09 uM and 0.072 uM, while sparing the wild type EGFR cell lines A549 and H2030..
In vivo	N/A.
Clinical Trials	N/A
Features	N/A

Description

ZM-306416 is a VEGFR antagonist and ZM-306416 can inhibit VEGFR with IC50 of 0.67 uM.

Targets

VEGFR

IC50

0.67 uM

In vitro

ZM-306416 is a VEGFR antagonist and ZM-306416 can inhibit VEGFR with IC50 of 0.67 uM. Sharing the 4-anilinoquinazoline scaffold common among EGFR kinase inhibitors such as erlotinib, gefitinib and lapatinib棓 ZM-306416 also shows potent inhibition to EGFR. ZM-306416 can potently inhibit the EGFR kinase with an IC50 value lower than 10 nM. ZM-306416 exhibits inhibitory activity across all three kinases of the panel, yielding IC50 values of 0.33 uM for SRC, 0.33 uM for VEGFR1, and 1.3 uM for ABL kinases. ZM-306416 can also induces selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 with IC50 of 0.09 uM and 0.072 uM, while sparing the wild type EGFR cell lines A549 and H2030..

In vivo

N/A.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

ZM306416由上海高创化学科技有限公司为您提供，货号K1288，规格：2mg，CAS号：690206-97-4，如您想了解更多关于ZM306416价格、ZM306416结构式、批发、用途等信息，欢迎咨询。除供应ZM306416外，还可为您提供重组人心肌营养素1/CTF1 Human、重组人卵泡抑素/Human FST His、兔子血清等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。