LY2784544|2mg|K1311-上海高创化学科技有限公司

SKU:K1311		M. Wt:469.94
Formula:C23H25ClFN7O		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:1229236-86-5		Synonyms:N/A
Chemical NameN/A

Description	LY2784544
Targets	JAK2 V617F
IC50	55 nM
In vitro	LY2784544 potently inhibited the JAK2 V617F-STAT5 signaling with IC50 of 55 nM, but the IC50 for inhibiting wild type JAK2 is 2.26 uM. LY2784544 selectively inhibit the JAK2 V617F-driven cell proliferation with IC50 of 68 nM.In Ba/F3 cell model, LY2784544 can inhibit JAK2 V617F signaling and induce apoptosis with EC50 of 113 nM.
In vivo	In vivo, LY2784544 effectively inhibits STAT5 phosphorylation in Ba/F3-JAK2 V617F-GFP ascites tumor cells with a Threshold Effective Dose 50 (TED50) of 12.7 mg/kg. LY2784544 also significantly duced Ba/F3-JAK2 V617F-GFP tumor burden in the JAK2 V617F-induced MPN model with a TED50 of 13.7 mg/kg after oral treatment (BID) for 14 days.LY2784544 selectively reduced Ba/F3-JAK2 V617F-GFP tumor cells with no effect on CD71/Ter119 positive erythroid progenitors in spleens of SCID mice after oral treatment (BID) for seven days.
Clinical Trials	N/A
Features	N/A

Description

LY2784544

Targets

JAK2 V617F

IC50

55 nM

In vitro

LY2784544 potently inhibited the JAK2 V617F-STAT5 signaling with IC50 of 55 nM, but the IC50 for inhibiting wild type JAK2 is 2.26 uM. LY2784544 selectively inhibit the JAK2 V617F-driven cell proliferation with IC50 of 68 nM.In Ba/F3 cell model, LY2784544 can inhibit JAK2 V617F signaling and induce apoptosis with EC50 of 113 nM.

In vivo

In vivo, LY2784544 effectively inhibits STAT5 phosphorylation in Ba/F3-JAK2 V617F-GFP ascites tumor cells with a Threshold Effective Dose 50 (TED50) of 12.7 mg/kg. LY2784544 also significantly duced Ba/F3-JAK2 V617F-GFP tumor burden in the JAK2 V617F-induced MPN model with a TED50 of 13.7 mg/kg after oral treatment (BID) for 14 days.LY2784544 selectively reduced Ba/F3-JAK2 V617F-GFP tumor cells with no effect on CD71/Ter119 positive erythroid progenitors in spleens of SCID mice after oral treatment (BID) for seven days.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

LY2784544由上海高创化学科技有限公司为您提供，货号K1311，规格：2mg，CAS号：1229236-86-5，如您想了解更多关于LY2784544价格、LY2784544结构式、批发、用途等信息，欢迎咨询。除供应LY2784544外，还可为您提供国产特级胎牛血清（无噬菌体低内毒素）、特级新生牛血清（无噬菌体低内毒素）、特级新生牛血清（无支原体）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。