TWS119|5mg|K1309-上海高创化学科技有限公司

SKU:K1309		M. Wt:318.33
Formula:C18H14N4O2		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:601514-19-6		Synonyms:N/A
Chemical NameN/A

Description	TWS119
Targets	GSK-3beta
IC50	30 nM
In vitro	TWS119, a 4,6-disubstituted pyrrolopyrimidine that can induce neurogenesis in murine ESCs. TWS119 can reduce beta-catenin phosphorylation and induce nuclear translocation of beta-catenin.TWS119 also elevate glutamine synthetase production, impede synthesis of alpha-smooth muscle actin and Wnt5a with promoting the expression of glial fibrillary acidic protein, Wnt10b, and paired-like homeodomain transcription factor 2c. Abeta(1-42) can be effectively prevented by treatment with the GSK-3beta inhibitor, TWS119, thereby implicating GSK-3beta kinase activity in this pathogenic cascade.
In vivo	N/A
Clinical Trials	N/A
Features	N/A

Description

TWS119

Targets

GSK-3beta

IC50

30 nM

In vitro

TWS119, a 4,6-disubstituted pyrrolopyrimidine that can induce neurogenesis in murine ESCs. TWS119 can reduce beta-catenin phosphorylation and induce nuclear translocation of beta-catenin.TWS119 also elevate glutamine synthetase production, impede synthesis of alpha-smooth muscle actin and Wnt5a with promoting the expression of glial fibrillary acidic protein, Wnt10b, and paired-like homeodomain transcription factor 2c. Abeta(1-42) can be effectively prevented by treatment with the GSK-3beta inhibitor, TWS119, thereby implicating GSK-3beta kinase activity in this pathogenic cascade.

In vivo

N/A

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

TWS119由上海高创化学科技有限公司为您提供，货号K1309，规格：5mg，CAS号：601514-19-6，如您想了解更多关于TWS119价格、TWS119结构式、批发、用途等信息，欢迎咨询。除供应TWS119外，还可为您提供重组人肌球蛋白轻链2(Recombinant Human MYL2)、Gibco山羊血清（新西兰）、热灭活胎牛血清（澳大利亚）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。