NVP-BSK805|2mg|K1306-上海高创化学科技有限公司

SKU:K1306		M. Wt:563.47
Formula:C27H28F2N6O.2HCl		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:1092499-93-8 (free base)		Synonyms:N/A
Chemical NameN/A

Description	NVP-BSK805
Targets	JAK2
IC50	0.5 nM
In vitro	NVP-BSK805 can potently suppress JAK2 with IC50 of 0.5 nM, and displays more than 20-fold selectivity towards JAK1, JAK3, and TYK2. NVP-BSK805 shows inhibition to causes JAK2V617F and JAK2 wild-type with IC50 of 0.5 nM. For cell lines, NVP-BSK805 inhibt JAK2V617F cells (Ba/F3) growth and induce cell apoptosis. NVP-BSK805 also can potently inhibit STAT5. By inducing activation of caspase cascades, NVP-BSK805 triggered cell death.
In vivo	In a Ba/F3 JAK2V617F cell driven mouse model, oral administration of NVP-BSK805(150 mg/kg) shows suppression to STAT5 phosphorylation, splenomegaly, and leukemic cell spreading.
Clinical Trials	N/A
Features	N/A

Description

NVP-BSK805

Targets

JAK2

IC50

0.5 nM

In vitro

NVP-BSK805 can potently suppress JAK2 with IC50 of 0.5 nM, and displays more than 20-fold selectivity towards JAK1, JAK3, and TYK2. NVP-BSK805 shows inhibition to causes JAK2V617F and JAK2 wild-type with IC50 of 0.5 nM. For cell lines, NVP-BSK805 inhibt JAK2V617F cells (Ba/F3) growth and induce cell apoptosis. NVP-BSK805 also can potently inhibit STAT5. By inducing activation of caspase cascades, NVP-BSK805 triggered cell death.

In vivo

In a Ba/F3 JAK2V617F cell driven mouse model, oral administration of NVP-BSK805(150 mg/kg) shows suppression to STAT5 phosphorylation, splenomegaly, and leukemic cell spreading.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

NVP-BSK805由上海高创化学科技有限公司为您提供，货号K1306，规格：2mg，CAS号：1092499-93-8，如您想了解更多关于NVP-BSK805价格、NVP-BSK805结构式、批发、用途等信息，欢迎咨询。除供应NVP-BSK805外，还可为您提供重组人β防御素118/DEFB118 Human、Gibco马血清（新西兰）、超级新生牛血清（无支原体）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海高创客户服务电话，售前、售后均可联系。