Telatinib (BAY 57-9352)|2mg|K1303-上海高创化学科技有限公司

SKU:K1303		M. Wt:409.83
Formula:C20H16ClN5O3		Solubility:No
Purity:>99%		Storage:2 years at -20 degrees centigrade
CAS No.:332012-40-5		Synonyms:N/A
Chemical NameN/A

Description	Telatinib (BAY 57-9352)
Targets	VEGFR2	VEGFR3	c-Kit	PDGFR-beta
IC50	6 nM	4 nM	1 nM	15 nM
In vitro	Telatinib (BAY 57-9352), a small molecule angiogenesis inhibitor, can potently inhibit VEGFR2, VEGFR3, c-Kit and PDGFRbeta with IC50 of 6 nM, 4 nM, 1 nM and 15 nM. Telatinib (BAY 57-9352) impairs vascular function, induces rarefaction, and causes hypertension. Telatinib can inhibit the autophosphorylation of VEGFR2 autophosphorylation with an IC50 of 19 nM, and telatinib also suppresses VEGF-dependent proliferation of human umbilical vein endothelial cells with an IC50 of 26 nM.
In vivo	The maximum-tolerated dose was not reached up to a dose of 1500 mg BID continuous dosing. Telatinib was rapidly absorbed with median t(max) of 3 hours or less.Telatinib is safe and well tolerated up to a dose of 1500 mg BID continuous dosing. Telatinib (450 mg b.i.d.) combined with bevacizumab (1 mg/kg bi-weekly) shows antitumor activity, but accumulating constitutional toxicity impedes long-term treatment of patients.
Clinical Trials	N/A
Features	N/A

Description

Telatinib (BAY 57-9352)

Targets

VEGFR2

VEGFR3

c-Kit

PDGFR-beta

IC50

6 nM

4 nM

1 nM

15 nM

In vitro

Telatinib (BAY 57-9352), a small molecule angiogenesis inhibitor, can potently inhibit VEGFR2, VEGFR3, c-Kit and PDGFRbeta with IC50 of 6 nM, 4 nM, 1 nM and 15 nM. Telatinib (BAY 57-9352) impairs vascular function, induces rarefaction, and causes hypertension. Telatinib can inhibit the autophosphorylation of VEGFR2 autophosphorylation with an IC50 of 19 nM, and telatinib also suppresses VEGF-dependent proliferation of human umbilical vein endothelial cells with an IC50 of 26 nM.

In vivo

The maximum-tolerated dose was not reached up to a dose of 1500 mg BID continuous dosing. Telatinib was rapidly absorbed with median t(max) of 3 hours or less.Telatinib is safe and well tolerated up to a dose of 1500 mg BID continuous dosing. Telatinib (450 mg b.i.d.) combined with bevacizumab (1 mg/kg bi-weekly) shows antitumor activity, but accumulating constitutional toxicity impedes long-term treatment of patients.

Clinical Trials

N/A

Features

N/A

工商信息

企业名称

上海高创化学科技有限公司

企业信息已认证

企业类型

信用代码

310228001353263

成立日期

2010-06-05

注册资本

经营范围

从事化学科技、计算机领域内技术开发、技术咨询、技术服务,从事生物科技领域内技术开发、技术咨询,化学试剂、化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备(除医疗器械),仪器仪表,Ⅰ类医疗器械,金属制品,电子产品,机电产品销售。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

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