SKU:K1294 | M. Wt:534.43 | ||
Formula:C23H21F7N4O3 | Solubility:N/A | ||
Purity:>99% | Storage:2 years -20°C Powder | ||
CAS No.:170729-80-3 | Synonyms:MK-869, L-754030, Emend | ||
Chemical NameN/A |
SKU:K1294 | M. Wt:534.43 | ||
Formula:C23H21F7N4O3 | Solubility:N/A | ||
Purity:>99% | Storage:2 years -20°C Powder | ||
CAS No.:170729-80-3 | Synonyms:MK-869, L-754030, Emend | ||
Chemical NameN/A |
Description | The substance P receptor antagonist MK-0869 shows antidepressant and anxiolytic activity in depressed outpatients which was comparable to a standard SSRI. | |||||
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Targets | ||||||
IC50 | N/A | |||||
In vitro | MK-869 is the substance P inhibitor. MK-869 showed antidepressant and anxiolytic activity. | |||||
In vivo | The substance P receptor antagonist MK-0869 shows antidepressant and anxiolytic activity in depressed outpatients which was comparable to a standard SSRI.In a 4 h observation period, MK-0869 and L-758,298 (3 mg/kg i.v. or p.o.) inhibited the emetic response to cisplatin (10 mg/kg i.v.).In a model of acute and delayed emesis, Pretreatment with MK-0869 (4-16 mg/kg p.o.) dose-dependently inhibited the emetic response to cisplatin. Once daily oral administration of MK-869 was effective in reducing delayed emesis and nausea after high-dose cisplatin. | |||||
Clinical Trials | N/A | |||||
Features | N/A |
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