SKU:K1293 | M. Wt:380.39 | ||
Formula:C21H20N2O5 | Solubility:No | ||
Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
CAS No.:172732-68-2 | Synonyms:LY-333013 | ||
Chemical NameN/A |
SKU:K1293 | M. Wt:380.39 | ||
Formula:C21H20N2O5 | Solubility:No | ||
Purity:>99% | Storage:2 years at -20 degrees centigrade | ||
CAS No.:172732-68-2 | Synonyms:LY-333013 | ||
Chemical NameN/A |
Description | LY315920(Varespladib) | |||||
---|---|---|---|---|---|---|
Targets | sPLA2 | |||||
IC50 | 9 nM | |||||
In vitro | LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). LY315920 inhibited sPLA2 activity with an IC50 of 9 nM. LY315920 was 40-fold less active against human, group IB, pancreatic sPLA2 and was inactive against cytosolic PLA2 and the constitutive and inducible forms of cyclooxygenase. | |||||
In vivo | LY315920 to transgenic mice expressing the human sPLA2 protein inhibited serum sPLA2 activity in a dose-related manner over a 4-h time course. In a model of acute pancreatitis in rats, the potent inhibitor of secretory phospholipase A2 (sPLA2), S-5920/LY315920Na significantly reduced mortality at 7 days, and strongly abrogated PLA2 activities in both plasma and ascites along with significant reduction of lipase activity, amylase, aspartate aminotransferase, and hemorrhage. Treatment with S-5920/LY315920Na 1 hr after OA infusion, but not 2 hrs after infusion, significantly attenuated the lung injury, as estimated by hypoxemia, decreased lung compliance, pulmonary edema, and vascular permeability. | |||||
Clinical Trials | N/A | |||||
Features | N/A |
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上海高创化学科技有限公司
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