Benzoylated ethyl 1-thioglycosides direct preparation from per-O-benzoylated sugars through Biotage Isolera耐士科技
2015-02-13 10:11
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资料摘要:
D-Glucose, lactose, maltose, and melibiose were benzoylated with Bz2O–Et3N reagent to give fully benzoylated b products. Under the same conditions, D-mannose produced a mixture where the b-benzoate predominated. Treatment of the foregoing compounds with EtSH at slightly elevated temperature (50–60 C) in the presence of BF3Et2O as a promoter gave the corresponding ethyl 1-thio glycosides in high yields. The a-products predominated in all cases in the anomeric mixtures formed. Individual products of all reactions were isolated by chromatography, they were obtained in analytically pure state, and were fully characterized by 1H and 13C NMR data and physical constants.
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enzoylatedethyl1thioglycosidesdirectpreparationfromperbenzoylatedsugarsthroughiotagesolera耐士科技.pdf
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We herein report several highly active catalyst systems with thiadiazolidine 1-oxides as ligands for palladium in the MizorokieHeck reaction. Excellent yields of stilbenes derived from aryl iodides and bromides have been achieved using as little as 0.00002 mol % catalyst. The ligand/palladiumsystem can be stored as a stock solution open to air at room temperature with no observable loss of activity for a period of several months.
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耐士科技作为Biotage中国区总代理,以优质的服务为您提供Biotage全系产品以及相关的技术服务。
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1.开机,按屏幕左下方黑色电源键
2.进入开机界面后,点击
Organic Synthesis
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