Recombinant Human CD146

CD146 Human
CD146 Human Recombinant
Catalog No. PRO-473

Synonyms:
Cell surface glycoprotein MUC18, Melanoma-associated antigen MUC18, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, S-endo 1 endothelial-associated antigen, Cell surface glycoprotein P1H12, CD146 antigen, MCAM, CD146, MUC18.

Introduction:
CD146 belongs to the immunoglobulin supergene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions. CD146 has a molecular size of 130 kDa in its reduced form (118 kDa unreduced), and N linked glycosylation accounts for fifty percent of the apparent molecular weight. In some cells the molecule carries a sulfate 3 glucuronyl moiety.

Description:
CD146 Human Recombinant (aa 433-647) expressed in E.coli, shows a 47 kDa band on SDS-PAGE.
The CD146 is purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearance:
Sterile Filtered clear solution.

Formulation:
CD146 at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.

Stability:
Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Applications:
• ELISA
• Inhibition Assays
• Western Blotting

Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.