重组人胰岛素降解酶（Human Insulysin）

Insulysin Human
Insulin Degrading Enzyme Human Recombinant
Catalog No. ENZ-384

Synonyms:
Insulinase, Insulin protease, Insulysin, Insulin-degrading enzyme, IDE, FLJ35968.

Introduction:
Insulysin is involved in cellular processing of insulin and in intercellular peptide signaling.
insulin-degrading enzyme is plays a role in the termination of the insulin response.

Description:
Insulysin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain cotaning 990 amino acids (41-1018 a.a.) and having a molecular mass of 108.9 kDa.
The Insulysin is fused to a 12 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Source:
Escherichia Coli.

Physical Appearence:
Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation:
Lyophilized with no additives.

Solubility:
It is recommended to reconstitute the lyophilized Insulysin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Stability:
Lyophilized Insulysin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Insulysin Recombinant should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Purity:
Greater than 90.0% as determined by SDS-PAGE.

Amino Acid Sequence:
MHHHHHHAAG IPMNNPAIKR IGNHITKSPE DKREYRGLEL ANGIKVLLIS DPTTDKSSAA LDVHIGSLSD PPNIAGLSHF CEHMLFLGTK KYPKENEYSQ FLSEHAGSSN AFTSGEHTNY YFDVSHEHLE GALDRFAQFF LCPLFDESCK DREVNAVDSE HEKNVMNDAW RLFQLEKATG NPKHPFSKFG TGNKYTLETR PNQEGIDVRQ ELLKFHSAYY SSNLMAVCVL GRESLDDLTN LVVKLFSEVE NKNVPLPEFP EHPFQEEHLK QLYKIVPIKD IRNLYVTFPI PDLQKYYKSN PGHYLGHLIG HEGPGSLLSE LKSKGWVNTL VGGQKEGARG FMFFIINVDL TEEGLLHVED IILHMFQYIQ KLRAEGPQEW VFQECKDLNA VAFRFKDKER PRGYTSKIAG ILHYYPLEEV LTAEYLLEEF RPDLIEMVLD KLRPENVRVA IVSKSFEGKT DRTEEWYGTQ YKQEAIPDEV IKKWQNADLN GKFKLPTKNE FIPTNFEILP LEKEATPYPA LIKDTAMSKL WFKQDDKFFL PKACLNFEFF SPFAYVDPLH CNMAYLYLEL LKDSLNEYAY AAELAGLSYD LQNTIYGMYL SVKGYNDKQP ILLKKIIEKM ATFEIDEKRF EIIKEAYMRS LNNFRAEQPH QHAMYYLRLL MTEVAWTKDE LKEALDDVTL PRLKAFIPQL LSRLHIEALL HGNITKQAAL GIMQMVEDTL IEHAHTKPLL PSQLVRYREV QLPDRGWFVY QQRNEVHNNC GIEIYYQTDM QSTSENMFLE LFCQIISEPC FNTLRTKEQL GYIVFSGPRR ANGIQGLRFI IQSEKPPHYL ESRVEAFLIT MEKSIEDMTE EAFQKHIQAL AIRRLDKPKK LSAECAKYWG EIISQQYNFD RDNTEVAYLK TLTKEDIIKF YKEMLAVDAP RRHKVSVHVL AREMDSCPVV GEFPCQNDIN LSQAPALPQP EVIQNMTEFK RGLPLFPLVK PHINFMAAKL

Usage:
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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