BACE1 Human
Beta-Site APP-Cleaving Enzyme 1 Human Recombinant
Catalog No. ENZ-358
Synonyms:
ASP2, BACE, HSPC104, Memapsin-2, Aspartyl protease 2, Asp 2, BACE1, Beta-secretase 1, EC 3.4.23.46, Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, FLJ90568, KIAA1149.
Introduction:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. BACE1 is a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.
BACE1 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE-1 cleaves at the n-terminus of the a-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated c-terminal fragment which is later released by gamma-secretase
Description:
BACE-1 Human Recombinant is expressed in E. coli containing 366 amino acids 28-393.
The BACE1 is purified by proprietary chromatographic techniques.
Source:
Escherichia Coli.
Physical Appearance:
Sterile Filtered clear solution.
Formulation:
20mM Tris, 20mM KCl, 0.3M NaCl and 10% glycerol, pH 7.8.
Stability:
Store at 4°C if entire vial will be used within 1-2 weeks.
Store, frozen at -20°C for longer periods of time.
Please prevent freeze-thaw cycles.
Purity:
Greater than 95% as determined by SDS-PAGE.
Applications:
Recombinant BACE-1 is an excellent protein for proteases functional assays; highly active, excellent for BACE-1 inhibitor screen assay.
Usage:
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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人β位淀粉样前体蛋白裂解酶1(BACE1)ELISA kit文献
产品类型:ELISA Kit 产品名称:人β位淀粉样前体蛋白裂解酶1(BACE1)ELISA kit 英文名称:Human β-site APP-Cleaving Enzyme 1,BACE1 ELISA kit 货号:CSB-E09824h 规格: 96T 种属: Human 其他种属:Bovine Guinea pig Mouse Rat 待测物名称: beta-site APP-cleaving enzyme 1 缩写: BACE1 检测范围: 3.12 pg/ml-200 pg/ml 灵敏度: 0.78pg/ml 反应时间: 1-5h 所需样本体积: 50-100ul 检测波长: 450 nm
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2014/07/08
人β位淀粉样前体蛋白裂解酶1(BACE1)ELISA kit说明书
产品类型:ELISA Kit 产品名称:人β位淀粉样前体蛋白裂解酶1(BACE1)ELISA kit 英文名称:Human β-site APP-Cleaving Enzyme 1,BACE1 ELISA kit 货号:CSB-E09824h 规格: 96T 种属: Human 其他种属:Bovine Guinea pig Mouse Rat 待测物名称: beta-site APP-cleaving enzyme 1 缩写: BACE1 检测范围: 3.12 pg/ml-200 pg/ml 灵敏度: 0.78pg/ml 反应时间: 1-5h 所需样本体积: 50-100ul 检测波长: 450 nm
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2014/07/08
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企业名称
上海希美化学有限公司
企业信息已认证
企业类型
信用代码
310228001203103
成立日期
2009-05-31
注册资本
10
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