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Catalogue Number |
ANT-269 |
|
Type |
Mouse Antibody Monoclonal. |
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Introduction |
MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded. |
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Clone |
NYRmI-A. |
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Immunogen |
Purified mouse LN B cells (C3H anti-C57Bl6). |
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Ig Subclass |
Mouse IgG2a. |
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Specificity |
Recognizes most MHC class II haplotypes (b,f,p,q,r,s,u,v), but weak against I-Ak. |
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Purification Method |
Ion exchange column. |
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Protein concentration |
1mg/ml in PBS (after reconstitution). |
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Storage Procedures |
Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |
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Reconstitution |
Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf LifeTwo years lyophilized, one month in solution at 4°C. |
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Antibody Properties |
Cytotoxic and staining antibody. For staining, use 10 ml/106 cells. Titer for cytotoxicity should be determined by the investigator. |
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Available Conjugates |
This antibody is also available unconjugated and conjugated to FITC. |
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Usage |
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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企业名称
上海希美化学有限公司
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企业类型
信用代码
310228001203103
成立日期
2009-05-31
注册资本
10
经营范围
化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海希美化学有限公司
公司地址
上海市松江区陆家圈路168弄113号
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公司名称： 上海希美化学有限公司
公司地址： 上海市松江区陆家圈路168弄113号 联系人： 李保平 邮编： 201619
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