alkaline phosphatase(liver/bone/kidney)antibody

alkaline phosphatase(liver/bone/kidney)antibody
Cat.#: S2051
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P05186
Mol Weight: 57.31kDa
Size: 100ul

Description
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq]

Recommended Applications
WB, IHC

Applications and Recommended Dilution Factors
WB: 1:500-1:3000
IHC: 1:100-1:500

Species Reactivity
Human

Other species have not been tested

Products Data 

Specificity
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 369 of alkaline phosphatase (liver/bone/kidney)

Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.

Alternative Names
ALPL antibody, AP-TNAP antibody, APTNAP antibody, FLJ40094 antibody, FLJ93059 antibody, HOPS antibody, MGC161443 antibody, MGC167935 antibody, TNAP antibody, TNSALP antibody, Alkaline phosphatase, tissue-nonspecific isozyme antibody, Alkaline phosphatase liver/bone/kidney isozyme antibody