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Mouse Anti Human FAS (CD95) Blocking/Activating

供货周期：一周

品牌：

规格： 500ug

货号： ANT-204

CAS号：

报价：面议

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产品介绍

Catalogue Number

ANT-204

Synonyms

FASLG receptor, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, CD95, Tumor necrosis factor receptor superfamily member 6 TNR6, APT1, FAS1, TNFRSF6.

Type

Mouse Anti Human Monoclonal.

Introduction

The Fas receptor (CD95) mediates apoptotic signaling by Fas-ligand expressed on the surface of other cells. The Fas-FasL interaction plays an important role in the immune system and lack of this system leads to autoimmunity, indicating that Fas-mediated apoptosis removes self-reactive lymphocytes. Fas signaling is also involved in immune surveillance to remove transformed cells and virus infected cells. Binding of FAS to oligimerized FasL on another cell activates apoptotic signaling through a cytoplasmic domain termed the death domain that interacts with signaling adaptors including FAF, FADD and DAX to activate the caspase proteolytic cascade. Caspase-8 and caspase-10 are first activated, to then cleave and activate downstream caspases, and a variety of cellular substrates that lead to cell death. Caspases cleave nuclear lamins, causing the nucleus to break down and lose its normal structure and another caspase substrate is DFF, inducing cleavage and degradation of the genome. Other caspase substrates are involved in cytoskeletal structure, cell cycle regulation and signaling pathways. Activation of JNK kinase, activation of Jun, and production of ceramide may also play roles in Fas-mediated apoptosis. Activation of fas-mediated apoptosis is opposed by I-FLICE and FAP. Viruses and tumors may escape immune surveillance in part through suppression of fas-mediated apoptosis using similar mechanisms.

Clone

NYRhFAS.

Immunogen

Recombinant Human FAS.

Ig Subclass

mouse IgG1.

Purification Method

Protein-A column.

Protein concentration

1 mg/ml in PBS (after reconstitution).

Shipping Conditions

Antibody is shipped lyophilized at ambient temperature.

Storage Procedures

In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

Reconstitution

Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. Stability / Shelf LifeTwo years lyophilized, one month in solution at 4°C.

Titer

By direct ELISA, 1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories).

Additional Information

This antibody is a BLOCKING antibody when in soluble form and will block FAS-mediated apoptosis. It will ACTIVATE FAS-mediated killing when immobilized.

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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工商信息

企业名称

上海希美化学有限公司

企业信息已认证

企业类型

信用代码

310228001203103

成立日期

2009-05-31

注册资本

经营范围

化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】

联系方式

上海希美化学有限公司

公司地址

上海市松江区陆家圈路168弄113号

客服电话

Mouse Anti Human FAS (CD95) Blocking/Activating 由上海希美化学有限公司为您提供，货号ANT-204，规格：500ug，CAS号：，如您想了解更多关于Mouse Anti Human FAS (CD95) Blocking/Activating 价格、Mouse Anti Human FAS (CD95) Blocking/Activating 结构式、批发、用途等信息，欢迎咨询。除供应Mouse Anti Human FAS (CD95) Blocking/Activating 外，还可为您提供Recombinant Human CD9、Recombinant Human CD95, His Tag、Mouse Anti Human Caspase-2 （CASP2）等试剂，公司有专业的客户服务团队，是您值得信赖的合作伙伴，上海希美化学客户服务电话，售前、售后均可联系。

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公司名称：上海希美化学有限公司

公司地址：上海市松江区陆家圈路168弄113号联系人：李保平邮编： 201619

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