ADRA2B Antibody(Center)
Cat.#: T3257
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P18089
Mol Weight: 50kDa
Size: 100ug
Description
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
Recommended Applications
WB, IHC, FC, ELISA
Applications and Recommended Dilution Factors
WB: 1:100~500
IHC: 1:50~100
FC: 1:10~50
ELISA: 1:1,000
Species Reactivity
Human
Products Data
Specificity
This ADRA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349~378 amino acids from the Center region of human ADRA2B.
Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Names
ADRA2B antibody, ADRA2L1 antibody, ADRA2RL1 antibody, ADRARL1 antibody, ALPHA2BAR antibody, Alpha-2B adrenergic receptor antibody, Alpha-2 adrenergic receptor subtype C2 antibody, Alpha-2B adrenoreceptor antibody
Description References
Tabakoff,B., et.al., BMC Biol. 7, 70 (2009)
Weinshank,R.L., et.al. Mol. Pharmacol. 38 (5), 681-688 (1990)
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企业名称
上海希美化学有限公司
企业信息已认证
企业类型
信用代码
310228001203103
成立日期
2009-05-31
注册资本
10
经营范围
化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海希美化学有限公司
公司地址
上海市松江区陆家圈路168弄113号
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