Aurora-A(AURKA)antibody
Cat.#: 3858-1
Rabbit Monoclonal Antibody
Clone ID: EPR5026
Swiss Prot: O14965
Mol Weight: 46kDa
Size: 100ul
Description
Aurora-A is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Aurora-A is ubiquitously expressed and activated through an interaction with Ajuba and TPX2 during late G2 and mitotic phases. Activated form regulates the functions of centrosomes, spindles, and kinetochores required for normal mitotic progression. Initially localized at centrosome during interphase, Aurora-A is translocated to mitotic spindles in early mitotic phase and finally degraded after metaphase/anaphase transition (2). Overexpression of Aurora-A is seen various tumors; overexpression can induce abnormalities in G2 and spindle checkpoints, and cytokinesis failure (3).
Recommended Applications
WB, ICC, FC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
ICC: 1:100 - 250
FC: 1:100 - 500
Species Reactivity
Human, Mouse
Species cross-reactivity is based on WB analysis
Products Data
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Specificity
A synthetic peptide corresponding to residues in human Aurora-A was used as an immunogen.
Storage Condition and Buffer
Store at -20° 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
AURKA antibody, AIK antibody, ARK1 antibody, AURA antibody, AURORA2 antibody, BTAK antibody, MGC34538 antibody, STK15 antibody, STK6 antibody, STK7 antibody, Serine/threonine-protein kinase 6 antibody, Breast tumor-amplified kinase antibody, Serine/threonine-protein kinase 15 antibody, Serine/threonine-protein kinase aurora-A antibody
Description References
1. Katayama H, et al. Cancer Metastasis Rev. 22(4): 451-64, 2003
2. Duct D et al, Exp Cell Res. 15;301(1):60-7, 2004.
3. Murimoto T et al, Nat Rev Cancer. Jan;5(1):42-50, 2005.
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企业名称
上海希美化学有限公司
企业信息已认证
企业类型
信用代码
310228001203103
成立日期
2009-05-31
注册资本
10
经营范围
化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海希美化学有限公司
公司地址
上海市松江区陆家圈路168弄113号
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