ASIP(PARD3)antibody

ASIP(PARD3)antibody
Cat.#: 1694-1
Rabbit Monoclonal Antibody
Clone ID: EP310Y
Swiss Prot: Q8TEW0
Mol Weight: 150kDa
Size: 100ul

Description
The agouti signaling protein (ASIP) is an adaptor protein involved in asymmetrical cell division and cell polarization processes. ASIP seems to play a central role in the formation of epithelial tight junctions. ASIP may affect the quality of hair pigmentation, and act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone (2-3). ASIP may also play a role in neuroendocrine aspects of melanocortin action, and have a functional role in regulating lipid metabolism in adipocytes (4-5).

Recommended Applications
WB, FC

Applications and Recommended Dilution Factors
WB: 1:500
FC: 1:20

Species Reactivity
Human

Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis of anti-ASIP RabMAb (cat. # 1694-1), dilution 1:500. A: LNCap B: Hela C: A431 D: MCF-7

Specificity
A synthetic peptide corresponding to residues near the C-terminus of human ASIP was used as immunogen. This antibody is predicted to detect isoforms 2-7 based on sequence analysis.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
PARD3 antibody, ASIP antibody, Baz antibody, Bazooka antibody, FLJ21015 antibody, PAR3 antibody, PAR3alpha antibody, PARD3A antibody, SE2-5L16 antibody, SE2-5LT1 antibody, SE2-5T2 antibody, Partitioning defective 3 homolog antibody, CTCL tumor antigen se2-5 antibody, PAR3-alpha antibody

Description References
1. Kwon, et al Proc. Nat. Acad. Sci. 91: 9760-9764, 1994.
2. Hu Y, Fang C, Xu Y.2005, Cell Mol Life Sci. Sep;62(17):1974-83.
3. Bonilla et al.2005 Hum Genet. Apr;116(5):402-6. Epub 2005 Feb 22.
4. Landi et al. 2005 J Natl Cancer Inst. Jul 6;97(13):998-1007.
5. Smith et al. Diabetes. 2003 Dec;52(12):2914-22.