ARG1 antibody
Cat.#: 5222-1
Rabbit Monoclonal Antibody
Clone ID: EPR6672(B)
Swiss Prot: P05089
Mol Weight: 35kDa
Size: 100ul
Description
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform ARG1 is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia (1).
Recommended Applications
WB, IHC, ICC, IP
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:250 - 500
ICC: 1:50 - 100
IP: 1:10 - 100
Species Reactivity
Human
Species cross-reactivity is based on WB analysis.
Products Data
Western blot analysis on (A) fetal liver and (B) fetal lung lysates using anti-ARG1 RabMAb (cat. #5222-1).
Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma tissue using anti-ARG1 RabMAb (cat. #5222-1).
Specificity
A synthetic peptide corresponding to residues in human ARG1 was used as an immunogen.
Storage Condition and Buffer
Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
ARG1 antibody, - antibody, Arginase-1 antibody, Liver-type arginase antibody, Type I arginase antibody
Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.