Aquaporin 5(AQP5)antibody

Aquaporin 5(AQP5)antibody
Cat.#: 2768-1
Rabbit Monoclonal Antibody
Clone ID: EPR3747
Swiss Prot: P55064
Mol Weight: 27kDa
Size: 100ul

Description
Aquaporin 5 is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions (1). It is expressed in epithelia of lung, cornea, and various secretory glands; sites where extracellular osmolality is known to fluctuate (2). Expression of Aquaporin 5 may have pathophysiological implications attributed to a dysfunctional water regulation by Aquaporin 5such as endolymphatic hydrops (i.e. in Meniere's disease) or sensorineural hearing loss (i.e. in Sjögren's syndrome) (3). Up-regulation of Aquaporin 5 may be involved in differentiation of human gastric cancer cells (4).

Recommended Applications
WB, IHC, ICC

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:100 - 250

Species Reactivity
Human

Products Data 
 

Western blot analysis on (A) fetal lung and (B) SW480 cell lysates using anti-Aquaporin 5 RabMAb (cat. #2768-1).
Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-Aquaporin 5 RabMAb (cat. #2768-1).

Specificity
A synthetic peptide corresponding to residues in human Aquaporin 5 was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
AQP5 antibody, - antibody, Aquaporin-5 antibody, antibody

Description References
1. Da Silva N., et al. Biol Reprod. 74(2):427-38, 2006 2. NCBI Reference Sequence (RefSeq): a curated non- redundant sequence database of genomes, transcripts and proteins Pruitt KD, Tatusova, T, Maglott DR Nucleic Acids Res 2007 Jan 1;35(Database issue):D61-5 3. Sidhaye VK, et al. Proc Natl Acad Sci U S A. 103(12):4747-52, 2006 4. Hirt B, et al. The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph- endolymph barrier, Neuroscience, 2009 5. Watanabe T, et al. J Physiol Sci. 59(2):113-22, 2009