Alpha-1 Catenin(CTNNA1)antibody
Cat.#: 2028-1
Rabbit Monoclonal Antibody
Clone ID: EP1793Y
Swiss Prot: P35221
Mol Weight: 100kDa
Size: 100ul
Description
Cadherin and catenin compose cell adhesion complex and are indispensable for tight cell-cell adhesion. Dysfunction of this adhesion complex causes dissociation of cancer cells from primary tumor nodules, thus possibly contributing to cancer invasion and metastasis (1). At least three proteins (alpha, beta, and gamma catenin) comprise the cytoplasmic domain of the cadherin cell-cell adhesion complex. Data, with the reported structure of other catenin genes, suggest that vinculin and alpha-catenin generate a superfamily of proteins mediating membrane-cytoskeletal associations (2). Presenilin-1 (PS1) overexpression in human kidney cells enhances cell-cell adhesion and data show that PS1 incorporates into the cadherin/catenin adhesion system and regulates cell-cell adhesion. PS1 concentrates at intercellular contacts in epithelial tissue; in brain, it forms complexes with both E- and N-cadherin and concentrates at synaptic adhesions (3).
Recommended Applications
WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors
WB: 1:10,000 - 50,000
IHC: 1:100 - 250
ICC: 1:100 - 250
IP: 1:50
FC: 1:50
Species Reactivity
Human, Mouse, Rat
Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only
Products Data
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Specificity
A synthetic peptide corresponding to residues near the N-terminus of human α-1 catenin was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
CTNNA1 antibody, CAP102 antibody, FLJ36832 antibody, FLJ52416 antibody, Catenin alpha-1 antibody, Alpha E-catenin antibody, Cadherin-associated protein antibody, Renal carcinoma antigen NY-REN-13 antibody
Description References
1. Oda T, et al. Biochem Biophys 193(3):897-904, 1993
2. Rimm DL, et al. Biochem Biophys 203(3):1691-9, 1994
3. Georgakopoulos A, et al. Mol Cell 4(6):893-902, 1999
Product References
1. Lien WH, Gelfand VI, Vasioukhin V, α– E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic ,J. Cell Biol. 183 (2008) 989 - 997
[Application: IP]
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企业名称
上海希美化学有限公司
企业信息已认证
企业类型
信用代码
310228001203103
成立日期
2009-05-31
注册资本
10
经营范围
化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
上海希美化学有限公司
公司地址
上海市松江区陆家圈路168弄113号
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