Actin(ACTC1)antibody
Cat.#: 1844-1
Rabbit Monoclonal Antibody
Clone ID: EP184E
Swiss Prot: P68032
Mol Weight: 42kDa
Size: 100ul
Description
Actins are highly conserved proteins ubiquitously expressed in all eukaryotic cells. They comprise, along with microtubules, a major component of the cytoskeleton. Actin has been found to be expressed in at least six isomeric forms. It is expressed in heart and skeletal striated muscle tissue, and in certain smooth muscle tissues, regulating contractile potentials for these cells. It is also expressed in the cytoplasm of non-muscle cells, functioning to control cell structure and motility (1). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin), whose formation requires the Arp2/3 complex (2). It has been reported that actin is hyperphosphorylated in primary breast tumors (3). It has also been shown that actin dysfunction leads to certain types of heart failure (4).
Recommended Applications
WB, IHC, ICC, IP, FC
Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:100 - 200
ICC: 1:250 - 500
IP: 1:20
FC: 1:20
Species Reactivity
Human, Mouse, Rat
For Mouse, this antibody is recommended for WB only
Rat cross reactivity tested by western blot only
Products Data
Specificity
A synthetic peptide corresponding to residues near the N-terminus of human Actin was used as an immunogen. This Actin antibody recognizes all muscle actins.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
ACTC1 antibody, ACTC antibody, ASD5 antibody, CMD1R antibody, CMH11 antibody, LVNC4 antibody, Actin, alpha cardiac muscle 1 antibody, Alpha-cardiac actin antibody
Description References
1. Herman, I.M. Curr. Opin. Cell Biol. 5: 48–55, 1993. 2. Bailly, M., et al. Curr Biol. 11: 620–5, 2001. 3. Lim, Y.P., et al. Clin. Cancer Res. 10: 3980–3987, 2004. 4. Olson, T.M., et al. Science 280: 750–2, 1998.
Product References
1. Bhattacharya R, Gonzalez AM, DeBiase PJ, et al, Recruitment of vimentin to the cell surface by β3 integrin and plectin mediates adhesion strength ,J. Cell Sci.122 (2009) 1390 - 1400
2. Wang JJ, Hu HQ, Wang S, et al, The important role of actinin-like protein (AcnA) in cytokinesis and apical dominance of hyphal cells in Aspergillus nidulans ,Microbiology 155 (2009) 2714 - 2725
3. Bhattacharya R, Gonzalez AM, Debiase PJ, et al, Recruitment of vimentin to the cell surface by β3 integrin and plectin mediates adhesion strength ,J Cell Sci 122 (2009) 1390-1400
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企业名称
上海希美化学有限公司
企业信息已认证
企业类型
信用代码
310228001203103
成立日期
2009-05-31
注册资本
10
经营范围
化工原料及产品(除危险化学品、监控化学品、烟花爆竹、民用爆炸物品、易制毒化学品),实验室设备,仪器仪表,金属制品,电子产品,机电产品销售,从事化工科技、计算机科技领域内技术开发、技术咨询、技术服务。【依法须经批准的项目,经相关部门批准后方可开展经营活动】
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公司地址
上海市松江区陆家圈路168弄113号
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