ACE2 Monoclonal antibody

ACE2 antibody
Cat.#: 3583-1
Rabbit Monoclonal Antibody

Clone ID: EPR4435(2)
Swiss Prot: Q9BYF1
Mol Weight: 110kDa
Size: 100ul

Description
ACE2 belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of ACE2 suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, it is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63 (1).

Recommended Applications
WB, IHC, ICC, IP

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:50 - 100
IP: 1:10 - 100

Species Reactivity
Human, Mouse, Rat

Mouse cross reactivity tested by western blot and IHC
Rat cross reactivity tested by western blot only

Products Data  

Specificity
A synthetic peptide corresponding to residues in the extracellular domain of human ACE2 was used as an immunogen.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ACE2 antibody, ACEH antibody, DKFZp434A014 antibody, Processed angiotensin-converting enzyme 2 antibody, Metalloprotease MPROT15 antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.