ABCG5 antibody

ABCG5 antibody
Cat.#: 5275-1
Rabbit Monoclonal Antibody

Clone ID: EPR6203
Swiss Prot: Q9H222
Mol Weight: 75kDa
Size: 100ul

Description
ABCG5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCG5 is a member of the White subfamily. It functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. ABCG5 is expressed in a tissue-specific manner in the liver, colon, and intestine. Mutations in this protein may contribute to sterol accumulation and atheroschlerosis, and they have been observed in patients with sitosterolemia (1).

Recommended Applications
WB

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000

Species Reactivity
Human

Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) Ramos and (B) HepG2 cell lysates using anti-ABCG5 RabMAb (cat. #5275-1).

Specificity
A synthetic peptide corresponding to residues in human ABCG5 was used as an immunogen.

Storage Condition and Buffer
Store at -20° C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
ABCG5 antibody, STSL antibody, ATP-binding cassette sub-family G member 5 antibody, Sterolin-1 antibody

Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1;33:D54-8.