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Cat.#: 3359-1
Rabbit Monoclonal Antibody
Clone ID: EPR4433
Swiss Prot: P80404
Mol Weight: 50kDaSize: 100ul
Description
ABAT (4-aminobutyrate aminotransferase) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities (1).
Recommended Applications
WB, IHC, IP
Applications and Recommended Dilution Factors
WB: 1:10,000 - 50,000
IHC: 1:250 - 500
IP: 1:10 - 100
Species Reactivity
Human, Mouse, Rat
For Mouse, this antibody is recommended for WB only
Rat cross reactivity tested by western blot only
Products Data
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Western blot analysis on (A) HepG2, (B) SH-SY5Y, (C) fetal liver, (D) rat brain, (E) rat kidney, and (F) mouse brain lysates using anti-ABAT RabMAb (cat. #3359-1).
Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-ABAT RabMAb (cat. #3359-1).
Specificity
A synthetic peptide corresponding to residues in human ABAT was used as an immunogen.
Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Alternative Names
ABAT antibody, FLJ17813 antibody, FLJ30272 antibody, GABA-AT antibody, GABAT antibody, NPD009 antibody, 4-aminobutyrate aminotransferase, mitochondrial antibody, L-AIBAT antibody
Description References
1. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res. 2005 Jan 1; 33: D54-8.
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