生物纳米压痕数据组织细胞和软组织凝胶的纳米压痕数据汇总，最低测试的杨氏模量在400Pa的样品同样可以获得完美的压痕数据。

Abstract: Chemically synthesized PbS, CdSe, and CoPt3 nanocrystals (NCs) were self-assembled into highly periodic supercrystals. Using the combination of small-angle X-ray scattering, X-ray photoelectron spectroscopy, infrared spectroscopy, thermogravimetric analysis, and nanoindentation, we correlated the mechanical properties of the supercrystals with the NC size, capping ligands, and degree of ordering. We found that such structures have elastic moduli and hardnesses in the range of ∼0.2-6 GPa and 10-450 MPa, respectively, which are analogous to strong polymers. The high degree of ordering characteristic to supercrystals was found to lead to more than 2-fold increase in hardnesses and elastic moduli due to tighter packing of the NCs, and smaller interparticle distance. The nature of surface ligands also significantly affects the mechanical properties of NCs solids. The experiments with series of 4.7, 7.1, and 13 nm PbS NCs revealed a direct relationship between the core size and hardness/modulus, analogous to the nanoparticle-filled polymer composites. This observation suggests that the matrices of organic ligands have properties similar to polymers. The effective moduli of the ligand matrices were calculated to be in the range of ∼0.1-0.7 GPa.

This study utilizes the Evactron® D-C for TEMs. The "contamination-free TEM" allowed researchers to accomplish high-resolution carbon elemental mapping by energy-filtered transmission electron microscopy (EFTEM) on the nanostructure of soft materials. In addition, this study illustrates that although TEM cryo-observation is known to be effective in reducing specimen damage, it was not observed to help in carbon mapping, suggesting that the cooling of the specimen may actually increase the contamination deposition rate. In the case of polymers, the detection of carbon is much simpler than those of other light elements because of its high content. Being able to do carbon analysis by elemental mapping and EELS with high spatial resolution without problematic contamination could lead to improvements for various soft-material nanoanalyses by EFTEM. This study suggests that the analytical technique utilizing the "contamination-free TEM" also offers possibilities in studies requiring extended exposure time of the electron beam, such as EELS, nanobeam diffraction and electron tomography.

ABSTRACT We report the first nanoindentation studies of well-ordered nanocrystal supercrystals composed of 7 nm lead sulfide nanocrystals stabilized with oleic acid ligands as a model system. Their modulus and hardness were found to be similar to hard polymers at 1.7 GPa and 70 MPa, respectively, and the fracture toughness was 40 KPa/m1/2, revealing the brittle nature of these materials. The mechanical properties are dominated by the organic capping agents surrounding the inorganic cores. The close-packed structure distributes stress evenly increasing the modulus and hardness. The relatively short ligands are not likely to be highly interdigitated leading to low dissipation during crack propagation and a low-fracture toughness value.

BACKGROUND Electron microscopy is used to detect, measure, and analyze constituents present in very small areas of materials. Hydrocarbon contaminants adsorbed on the surface or as surface films interacting with the incident electron probe beam can distort the results. The distortion may take the form of deposits of polymer in the scanned area, a darkening of the scanned area, a loss of resolution, or other artifacts. Deposits created by the interaction of the probe beam with the surface specimen also may interfere with the probe beam or emitted electrons and x-rays and thus adversely affect accurate analysis. Deposits also add uncertainty to SEM measured line widths in semiconductor-device, critical-dimension metrology. These Hydrocarbons are present in trace levels in ordinary room air and come from living organisms and man-made material. All surfaces exposed to room air at atmospheric pressure accumulate these hydrocarbons. In the semiconductor industry, said contamination is known as Airborne Molecular Contamination or “AMC”. Reducing and controlling AMC is an active area of concern for semiconductor manufacturers as device dimensions move into the sub 100-nm range. Some of hydrocarbon molecules associated with AMC are large enough (1-10 nm) to be imaged with HR FESEM and interfere semiconductor lithography processes in the sub 100 nm range. Surfaces are further hydrocarbon contaminated by touching, the use of outgassing materials in vacuum system, or, in general, “poor vacuum practices.”

Getting the most out of your SEM has in the past meant baking out your column and being vigilant about wearing gloves when handling samples. As feature sizes decrease this may not be enough. Hydrocarbon buildup in SEM vacuum chambers can lead to less than ideal resolution. The electron beam reacts with contamination and deposits carbon on the sample which can cause charging and degrade image contrast. Oxygen plasma has long been used for cleaning surfaces in a vacuum. O2 is split into oxygen ions and radicals which are effective at removing organic contaminants. Manufacturers have produced low energy plasma cleaners that pull oxygen ions and radicals out of “thin air.” While this may seem like “snake oil”, it actually does work. This approach works, is easy to use, and has very little setup, but it is very slow. If you have a “dirty” system you may spend days or weeks on an initial cleaning. We modified our Evactron® De-Contaminator to use welding grade oxygen. The investigation that we have performed indicates that there is a night and day comparison for effectiveness and speed. One or two four hour sessions with oxygen was shown to be more effective than using ambient air for weeks.

In force measurements with micromachined cantilevers the application of Hooke's law ( F = −kx) requires two quantities: x, the distance the flexing cantilever moves and the spring constant, k.

针尖加强拉曼光谱活细胞成像——We labeled the living yeast cell surface
Saccharomyces cerevisiae strain W303-1A by silver nanoparticles which can form nanoaggregates and found to show surface enhanced Raman scattering
SERS activity. Blinking of SERS and its polarization dependence reveal that SERS signals are from amplified electromagnetic field at nanometric Ag nanoparticles gaps with single or a few molecules sensitivity. We tentatively assigned SERS spectra from a yeast cell wall to mannoproteins. Nanoaggregate-by-nanoaggregate variations and temporal fluctuations of SERS spectra are discussed in terms of inhomogeneous mannoprotein distribution on a cell wall and possible ways of Ag nanoaggregate adsorption, respectively

利用高次谐波成像技术实现超高分辨率的MFM分辨（商用化160G硬盘分析，10nm以下磁畴）。高次谐波成像技术相对传统的MFM速度快两倍，同时拥有更高的图像对比度和分辨率，获得更多的信号数据。

人体干细胞矩阵力测试。 Microenvironments appear important in stem cell lineage specification but can be difficult to adequately characterize or control with soft tissues. Naive mesenchymal stem cells (MSCs) are shown here to specify lineage andcommit to phenotypes with extreme sensitivity to tissuelevel elasticity. Soft matrices that mimic brain are neurogenic, stiffer matrices that mimic muscle are myogenic, and comparatively rigid matrices that mimic collagenous bone prove osteogenic. During the initial week in culture,reprogramming of these lineages is possible with addition of soluble induction factors, but after several weeks in culture, the cells commit to the lineage specified by matrix elasticity, consistent with the elasticity insensitive commitment of differentiated cell types. Inhibition of nonmuscle myosin II blocks all elasticitydirected lineage specification–without strongly perturbing many other aspects of cell function and shape. The results have significant implications for understanding physical effects of the in vivo microenvironment and also for therapeutic uses of stem cells.

Dual AC是一项由Asylum Research为MFP-3DTM系统发展出来的独一无二的全新测试能力。自从面世以来，Dual AC模式的应用领域不断的扩张。在本文中我们将会给您简单的介绍Dual AC模式中的高次谐波双峰成像模式。他将应用于静电力测试、磁力测试和压电力测试实验中

在本文中作者详细介绍了压电力显微技术的基本原理、发展方向和应用领域。其中对于压电显微技术在电机械性能测试、液相压电力测试、动态极化偏振测试做了着重的介绍。

Dual AC是一项由Asylum Research为MFP-3DTM系统发展出来的独一无二的全新测试能力。自从面世以来，Dual AC模式的应用领域不断的扩张。在本文中我们将会给您简单的介绍Dual AC模式中的高次谐波双峰成像模式在压电力显微镜上的应用。

双峰高次谐波成像得益于MFP-3D全数字化控制器强大的数字信号处理能力。隐藏在这个方法背后的想法非常简单，我们利用悬臂自身拥有多个共振频率来扩展悬臂的机械性能。在过去的轻敲模式中我们往往使用其中的一个共振频率来驱动悬臂，而大多情况下使用的悬臂的最低的共振基频，然后使用振动过程中的频率或是振幅输入反馈系统从而控制针尖与样品的距离。当我们使用振幅作为探针的驱动基本控制手段，这便是所谓的振幅调制原子力显微镜（AM-AFM）

008-7-9，Asylum Research仪器公司近日宣布其和橡树岭国家国家实验室产品能带激励（Band Excitation）荣获R&D 100大奖R&D 100奖被 Chicago Tribune称作“发明界的奥斯卡”,每年是由R&D杂志为当年最具创新和技术意义的100个上市产品颁发的奖项。R&D杂志的编辑和一个独立的工业专家组评选出优胜者。能带激励显微镜作为一项突破性的扫描探针显微镜技术，它对比以前的技术而言可以更加快速探测在纳米尺度的能量散射情况，能够帮助科学家在标准的扫描速率情况下判定样品的电学、磁学和机械能量的转换和散射。 “我们非常高兴可以获得如此殊荣” Asylum Research公司总裁Roger Proksch 评价道“在过去一年我们和橡树岭国家实验室紧密合作一起推进了扫描探针领域的前沿性发展，其中包括压电力模块（Piezo Force Module）和压电力转换谱模式”能带激励方法是一个在扫描探针领域中数据获取和处理的基础性的新方法。这个奖项肯定了Asylum Research 和我们的合作者一直领导着这个行业的技术创新所作出的巨大努力。

本篇文章是对王中林教授在Science上发表的纳米发电机实验的详细补充。具体详细阐述了纳米发电机的原理和实验过程。 纳米发电机无论在生物医学、军事、无线通信和无线传感方面都将有广泛的重要应用。他说：“这一发明可以整合纳米器件，实现真正意义上的纳米系统，它可以收集机械能，比如人体运动、肌肉收缩等所产生的能量；震动能，比如声波和超声波产生的能量；流体能量，比如体液流动、血液流动和动脉收缩产生的能量，并将这些能量转化为电能提供给纳米器件。这一纳米发电机所产生的电能足够供给纳米器件或系统所需，从而让无纳米器件或纳米机器人实现能量自供。”

世界最小发电机—纳米发电机 纳米发电机是基于规则的氧化锌纳米线的纳米发电机。在氧化铝衬底上生长的氧化锌纳米线，然后在导电的原子力显微镜针尖作用下，当原子力显微镜探针扫过纳米线阵列时，压电电荷释放的三维电压/电流信号图。 美国佐治亚理工学院教授、中国国家纳米科学中心海外主任王中林等成功地在纳米尺度范围内将机械能转换成电能，研制出世界上最小的发电机——纳米发电机。

蜘蛛丝分子是一种韧性极强的天然纤维材料。在本文中作者对单分子的蜘蛛丝进行了细致深入的研究。由于AR在分子力测定上强大的性能能够准确的测定单分子链接载荷在30pN以下的测定。

利用原子力显微镜观察仿生壁虎脚结构下微观粘附力的变化。在实验中作者使用了分析了阵列角度变化情况下粘附力曲线的不同。以及使用表面材料p(DMA-co-MEA)情况下粘附力的变化情况。

利用原子力纳米压痕技术全面在微纳尺度上分析人造骨表面的能量分布，是现有残余应力分析的最高分辨率水平。在本文中作者引入了一种在纳米压痕中使用IGOR软件对采集到的力曲线数据的分析新方法，同时利用有限元软件模拟分析了探针针头形状对于纳米压痕的效果影响。

AR公司同美国华盛顿大学的David C.Coffey教授合作开发了结合外部光源在时域范围内测试有机高分子薄膜在太阳能电池光生载流子的聚集和表面电势变化过程的时域原子力研究系统。