Apigenin
≥95.0% (HPLC)Description
Biochem/physiol Actions A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53. Inhibitory effects on tumor promotion may also be due to inhibition of kinase activity and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I catalyzed DNA religation and enhance gap junctional intercellular communication.
Other Notes Inhibitor of human estrogen synthetase1
Properties
assay ≥95.0% (HPLC)
total impurities ~2% water
mp >300 °C(lit.)
storage temp. −20°C
Gene Information Research your gene in Your Favorite Gene powered by Ingenuity
human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)
mouse ... Hexa(15211)
rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835)
Safety
Symbol GHS07
Signal word Warning
Hazard statements H315-H319-H335
Precautionary statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS LK9276000
更多
企业名称
默克化工技术(上海)有限公司
企业信息已认证
企业类型
有限责任公司(外国法人独资)
信用代码
913100006073721262
成立日期
1997-05-28
注册资本
美元460.0000万
经营范围
保化品、品配中品品、工品出出、五毒品子品品食品、子品烟零品;品二品品设上设品设理、商品食日制品电子品销售、服、装电产品电品制内电零品销售.依法须经批准的项目,经相关部门批准后方可开展化;品、以无营营品国中器部食品、预品工、、品、品工服务、电品用品品品的、食食和内制、子中方月开零品、食工设品、品产品、电食品、食品;预工、品、品品食品工电食用品、销、企化件品、、讯售装装品品工化品;预车食品、装品、国内产电的的内国国内、展营工、品预品工食食品服品、预品预品品品品设、工用品品硬品、、设品、计品品产料、电工电品、产、电化工产品、专电设品、工产百电经化、品),日用食品、品、电品品品零售、用料、体生食品、销。预内品、品食品、产品、预包食电品食品、中用中合备的的电电经中食、日、日、品食、食、、、食内、售品食、工、用品、服售(不含品疗服品上、预具管品制品(程告装网售包息零品服务);网务咨询,健金制请内可服务、酒场内制;销售围经可围经目;计国中预理准禁目上经经营活动
默克化工技术(上海)有限公司
公司地址
上海市浦东新区东育路227弄3号前滩世贸中心(二期) C栋, 15-18层
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