Quick and easy to use the THT µMC™ allows multiple samples (up to 8) be studied simultaneously. The µMC is a heat flow calorimeter whereby the difference between sample chamber temperature and jacket temperature is used to determine the enthalpy of a reaction. The peltier control makes for rapid equilibration. Low volume (1.5ml or 4.0ml) disposable cells can handle solids, liquids and mixtures. Sample quantities can range from milligrams to grams. A variety of operation modes are possible, namely Isothermal, Step-Isothermal or Scanning.

Itraconazole is a triazole derivative with a broad spectrum of antifungal activety. Many fungal strains have been effectively treated with the drug. The drug inhibits the synthesis of ergosterol, the primary sterol in fungi and yeast membranes, thus critically altering the permeability of the menbranes.

Dissolution measurements of soild dosage from phamaceutical products are traditionally carried out in standardized thermostatted baths accommodating USP volumes of 500 and 900 mL to maintain sink conditions during measurement.

Clotrimazole is an imidazole derivative with a broad spectrum of antifungal activity. The azole inhibits the synthesis of ergosterol, a major component of yeast and fungal cell membranes, altering their permeability.

Adsorption of Low Charge Density Polyelectrolyte Containing Poly Side Chains on Silica:Effects of Ionic Strength and pH Adsorption characteristies of a random copolumer of poly monomethyl ether......

Adsorption of a small protein to a methyl-terminated hydrephobic surfaces:effect of protein-folding thermodynamics and kinetics

Adsorption Behavior of Antimicrobial Peptide Histatin 5 on PMMA Department of Dental Materials Science and Oral Health Science Center......

A Multitechnique Study of Liposome Adsorption on Au and Lipid Bilayer Formation on SiO2 We have used a new setup for parallel quartz......

A Hexapeptide Motif that Electrostatically Binds to the Surface of Titanium With its light weight and toughness,tianium holds a special place among......

A Dual-Frequency QCM-D Setup Operating at Elevated Oscillation Amplitudes An often raised, but rarely addressed,question with respect to applications of the quartz.....

A comparative study of protein adsorption on titanium oxide surface using in situ ellipsometry,optical waveguide lightmode spectroscopy,and quartz crystal microbalance/dissipation

A Blank Slate? Layer-by-layer Deposition of Hyaluronic Acid and Chitosan onto Various Surfaces

We present a method for combined far-field Raman imaging, topography analysis and near-field spectroscopy. Surfaceenhanced Raman spectra of Rhodamine 6G (R6G) deposited on silver nanoparticles were recorded using a bent fibre aperture-type near-field scanning optical microscope (NSOM) operated in illumination mode. Special measures were taken to enable optical normal-force detection for control of the tip–sample distance. Comparisons between far-field Raman images of R6G-covered Ag particle aggregates with topographic images recorded using atomic force microscopy (AFM) indicate saturation effects due to resonance excitation.

The solvent composition induced reentrant behavior of poly(N-isopropylacrylamide) (PNIPAM) chains grafted on a SiO2 surface in water-methanol mixtures was investigated using a quartz crystal microbalance with dissipation monitoring (QCM-D) at 20 °C. The frequency and energy dissipation responses showed that the grafted PNIPAM chains sharply collapse when the methanol content (xm) reaches 17 mol %. In the range 17-50 mol %, the grafted chains remain in a collapsed state. Further increase of the methanol content leads to an abrupt reswelling of the collapsed chains at xm > 50 mol %. The sharp reentrant swelling-to-collapse-to-swelling transition was attributed to the water-methanol complexation instead of the preferential adsorption effect. Our results also suggest that the water-methanol complexation is not induced by hydrophobic interaction but by hydrogen bonding.

Thermally sensitive poly(N-isopropylacrylamide) (PNIPAM) brushes grafted on SiO2-coated quartz crystal surface were prepared with a surface-immobilized initiator. Using quartz crystal microbalance (QCM), we investigated the collapse and swelling of the brushes in water in real time. Both frequency and dissipation of PNIPAM brushes were found to gradually change throughout a temperature range 20-38 °C, indicating that PNIPAM brushes undergo a continuous collapse transition in contrast with PNIPAM chains free in dilute solution exhibiting a sharp coil-to-globule transition. This result is in accordance with the previous theoretical prediction. The nonuniformity and stretching of PNIPAM brushes as well as the cooperativity between collapse and dehydration transitions are thought to be responsible for the continuity. On the other hand, a hysteresis was also observed in the cooling process. This is not only due to the intrachain and interchain interactions formed in the collapsed state but also to the nonuniform structure and stretching of the high-density brushes.

Measurements at temperatures up to 700 oC are possible with specially designed MICA insulated Nickel sensors. In this application note an Inconel 600 sample, certified by National Physics Laboratory (NPL) in the UK and a brass sample from an industrial maker were measured with the Hot Disk Thermal Constants Analyser. A thick-muffle furnace was used for heating the samples.

In this application note, samples made out of a polycarbonate, Lexan 123 R, matrix reinforced with different amounts of nanofibres from Hyperion Catalysis (FIBRIL) are tested with the Hot Disk Thermal Constants Analyser and the anisotropic module. The fibers lie mainly in the plane of the sensor.

The Hot Disk Thermal Constants Analyser can be used for measurements on anisotropic samples such as stacks of metal sheets. In this application note sheets of transformer iron core samples were measured with both the slab technique in order to obtain the individual plate’s thermal conductivity, diffusivity and specific heat capacity and the anisotropic technique to find the properties of a stack of these plates.

A collection of AlSi7 closed cell foams of densities between 500 kg/m3 and 1300 kg/m3 were produced following the powder metallurgical route [1,2]. On the one hand, thermal conductivity of the samples has been measured by means of the transient plane source (TPS) technique [3,4]. Values obtained showed the increase of thermal conductivity values with density. On the other hand, the TPS technique has been tested as a tool to detect in-homogeneities derived from the manufacturing process. The results obtained have proved the ability of this method to detect these in-homogeneities, and its possible use as a non – destructive quality control method.

In this Application note four different milk products with fat content (given by the manufacturer) <0.1 %, 0.5 %,1.5 % and 3 % were compared in order to investigate if the Hot Disk Thermal Constants Anlyser can be used to determine fat content in diary products.

本文应用瞬态平面热源技术（Transient Plane Source Method, TPS）对热导率范围从0.028-166W/mK 之间的几个标准样品进行了测试，得到的数据与采用其他标准方法得到的数据非常吻合。实验结果表明，TPS 技术非常适合于测试固体材料的热扩散系数和热导率。它不需特别的样品制备，与其他方法相比，不仅精度较高，而且测试速度更为快捷。

Reaction Calorimetry allows vital data to be available for optimised and safe scale up. Testing carried out can fully characterise the kinetics of the process. It is possible to make a model of the reaction. Nevertheless there are potentially many scenarios that may require investigation during scale up. It is not appropriate to consider only the optimum processing scenario. The effects of temperature, of type and amount of impurity, additive (catalyst, inhibitor), the ratio of reagents, even the source of reagents. There are a large number of potential variations that can cause upset and these need to be quantified.Classical reaction calorimetry has the ability to mimic process conditions and thus such testing takes large volumes of reagents (that may not be available) and effort in terms of operator time and cost. This calls into question the practicability of such testing when really many tests need to be performed. Often an unsatisfactory compromise has to be reached where limited testing is carried out. The ability of micro reaction calorimetry to be able to perform most of the reaction calorimetry testing requirements of scale-up in a fraction of time with a fraction of the reagent requirement and at a fraction of the cost of full scale reaction calorimetry indicates the worth of such a technique. A micro reaction calorimeter has applications far beyond scale-up and reaction calorimetry itself. A micro reaction calorimeter is also a scanning calorimeter (a large volume DSC), an isothermal calorimeter (high sensitivity for stability studies), a properties calorimeter (for heat of solution, mixing and specific heats) and an isothermal titration calorimeter.

A new, novel Micro Reaction Calorimeter is described. Reaction calorimetry has applications in many areas of chemistry. A reaction calorimeter will measure heat output of chemical reaction you do or do not want (process optimisation and safety); kinetics of reaction and thermodynamics of reactions can be quantified. But, in addition, a reaction calorimeter will determine specific heat, heat of solution, heat of mixing. Solids, liquids or mixtures can be measured. Applications range from kinetic studies for process development to evaluation of catalysts or other additives; from stability of explosives to specific heat determination of heterogeneous mixtures. Pressure also can be measured. Until now, reaction calorimeters have been large glass vesselled instruments, have been of low sensitivity, slow in set-up and operation (1 test per day) and with a requirement often of 1 – 2 litres can cause hazard in operation or difficulty if sample availability is limited. Often commercially, they are very expensive. A Micro Reaction Calorimeter overcomes all these issues. Application of the Micro Reaction Calorimeter is detailed in this paper. Key words: reaction calorimeter; safety; process development; heat of reaction; kinetics; thermodynamics

Effective thermal conductivity (ETC) of both tetrahydrofuran (THF) and methane hydrate-bearing sandy porous media was measured by the Hot Disk Thermal Constant Analyser. Thermal conductivity of methane hydrate is 0.575 W m−1 K−1 at 0°C and 6.6 MPa (methane gas pressure), which is close to THF hydrate''s 0.51 W m−1 K−1 at 0°C and 0.1 MPa (atmosphere pressure). However, the measured 1 W m−1 K−1 ETC of methane hydrate-bearing sand is significantly lower than that of THF hydrate-bearing sand at ∼2 W m−1 K−1. This is because the methane hydrate formed with a sodium dodecyl sulfate (SDS) solution in sand at our laboratory has a “wall creeping” growth characteristic and consequently a large part of the pores were filled with methane free gas. ETCs of sand containing gas hydrates were also calculated using a renormalization method. The process involves sample partitioning, labeling, initial value assignments, and renormalization calculations. A Monte Carlo analysis was applied to sample laboratory-scale gas hydrate-bearing sand assemblies. We found that the renormalization modeling results agreed well with measured ETCs when each photo of a 1.3 mm × 1.3 mm subsample was divided into 16 or more blocks.