Theta QC 是一款设计精巧紧致的便携式光学界触角测试仪，可用于精确测试润湿，吸附，均一性，表面自由能，铺展性，吸收，清洁度，印刷适性等。本文主要介绍了Theta QC 光学接触角仪与达因笔测试法在质量控制应用上的比较

Theta QC 是一款设计精巧紧致的便携式光学界触角测试仪，可用于精确测试润湿，吸附，均一性，表面自由能，铺展性，吸收，清洁度，印刷适性等。本文主要介绍了Theta QC 光学接触角仪在包装工业的表面处理评价上的应用

DNA biosensors (or genosensors) are analytical devices that result from the integration of a sequence-specific probe and a signal transducer. Among other techniques, electrochemical and piezoelectric methods have recently emerged as the most attractive due to their simplicity, low instrumentation costs, possibility for real-time and label-free detection and generally high sensitivity. Focusing on the most recent activity of worldwide researchers, the aim of the present review is to give the readers a critical overview of some important aspects that contribute in creating successful genosensing devices. Advantages and disadvantages of different sensing materials, probe immobilisation chemistries, hybridisation conditions, transducing principles and amplification strategies will be discussed in detail. Dedicated sections will also address the issues of probe design and real samples pre-treatment. Special emphasis will be finally given to those protocols that, being implemented into an array format, are already penetrating the molecular diagnostics market.

Introduction In this application note an extruded PS sample certified by NIST has been tested with the Hot Disk Thermal Constants Analyser in order to compare the results with the results obtained with the methods used at other laboratories. By marking each side of each sample with “1” for low side and “2” for upper side, it was possible to test four permutations of the sample set-up and thus it could be possible to analyse possible differences between the upper side and the lower side of the samples as they were manufactured. Since the sample is formed by extrusion,it is assumed that the PS will have a higher density on the bottom side of the sample than the upper side and therefore different thermal properties.

are two possibilities; external and internal pressure. The battery being self contained will show no external pressure until release of a venting disc or disintegration, the gas released will react with oxygen in the environment. Such tests may simply be carried out by enclosing the battery in a holder. Earlier reported tests used a heavy close fitting container, such a holder compromises thermal data and might explode upon rapid gas release. The usefulness of this data might be questioned since there would be no pressure rise from the start of the test until battery ‘opening’ occurs and then there would be a simple single rapid pressure rise. Perhaps of more interest is the development of internal pressure, how this increases with temperature and the temperature and pressure that can be withstood before opening. For the first time we report calorimetric (thermal and pressure) data and though not shown here associated electrical data (voltage) can be recorded throughout the test. Tests have been carried out with ‘specimen’ 18650 batteries. For the test protocol, minor modifications are necessary to the ARC and to the battery itself. Here is reported the set up protocol, the experimentation and results.

We present a technique for in situ Raman measurements of suspended individual single-walled carbon nanotubes (SWNTs) under strain. We observe a strong change in the radial breathing mode intensity with increasing strain as the nanotube moves out of (or into) resonance, and for strain greater than 2%, there is a clear irreversible upshift in the G-mode frequencies accompanied by an increase in intensity of a broad peak at a position associated with the D mode. For lower strain, the G-mode peaks (A1, E1, and E2) do not change significantly in position but change in relative intensity.

本文介绍了Hot Disk瞬态平面热源法测试原理，以及采用Hot Disk瞬态平面热源法测试建筑材在不同含水率条件下导热系数的变化趋势。

OVERVIEW Hydroxyapatite (HA) is a calcium phosphate mineral (Ca10(PO4)6(OH)2) which is the main constituent in bone and teeth. HA is known for its special proper-ties, especially when in contact with living tissue. HA's bioactivity is ad-vantageous in a range of applica-tions, such as bone implants and stents. Due to HA’s unique similar-ity to the hard tissues found in bio-logical systems, it is widely used as reference material whenever inter-actions between hard tissues and biological species are of interest. Q-Sense collaborates with the company Promimic that has devel-oped a proprietary method to coat materials with nanocrystalline Hy-droxyapatite having high stability and smoothness, called Promimic HANANO.

With the Q-Sense E4 instrument, real-time studies of surface degradation processes are time efficient and easy to conduct. Our technology provides unique insight into the molecular events and structural changes at the surface – watch the break-up of films and mass removal as it happens directly on the screen, and follow swelling phenomena and desorption rates. Instrument flexibility is high, almost any model surface can be analyzed.

In this paper, the Raman intensity enhancement induced by nanoprobes (metal particles and metallized tips) in the vicinity of a strained silicon sample surface is reported. For silver nanoparticles deposited directly onto silicon, high enhancements in the vicinity of particles were observed. Furthermore, metallized tips were scanned inside the spot of a laser used for the Raman measurements. Both silver coated and pure silver tips, mounted to a tuning fork, indicated high Raman signal enhancement for optimized tip position within the laser spot. Atomic Force Microscopy (AFM) scanning on a structured sample was conducted to investigate the stability of these tips. Focused Ion Beam (FIB) milling was utilized to refine and to re-sharpen pure silver tips after the measurements. Complementary measurements were performed using pure tungsten tips. Because of the high hardness of W wires, a special pre-etch technique was applied.

We present a technique for in situ Raman measurements of suspended individual single-walled carbon nanotubes (SWNTs) under strain. We observe a strong change in the radial breathing mode intensity with increasing strain as the nanotube moves out of (or into) resonance, and for strain greater than 2%, there is a clear irreversible upshift in the G-mode frequencies accompanied by an increase in intensity of a broad peak at a position associated with the D mode. For lower strain, the G-mode peaks (A1, E1, and E2) do not change significantly in position but change in relative intensity.

It is shown that Raman intensities of bulk and film in silicon-on-insulator substrates strongly depend on the incident angle of the exciting laser. In a backscattering geometry with perpendicular laser incidence, deflection at particles or atomic force microscopy tips can thereby lead to a selective enhancement of the film signal, which can be misinterpreted as surface/tip enhanced Raman scattering. The authors report strong enhancement effects by scattering at dielectric particles on silicon-on-insulator and silicon substrates as well as smaller effects for deflection at tips. In evaluating field enhancements on such substrates, this must be considered.

In this work we have studied the optical activity of chiral crystal surfaces with polarized near-field scanning optical microscopy (NSOM); our studies clearly demonstrated that polarized NSOM can be utilized to determine chirality at crystal surfaces.

In the present study, the polarization properties of propagation light within a polymeric optical waveguide were characterized by means of a polarized guide-collection-mode near-field scanning optical microscopy
NSOM technique, and changes in the polarization properties around an indentation were evaluated. When transverse magnetic polarized light enters a waveguide, the light intensity becomes greater on the near side of the indentation than on the far side, as measured by a linearly polarized component perpendicular to the direction of light propagation. The most probable cause of this phenomenon is microdefects generated by the printing of the indentation. The polarized NSOM technique is useful in searching for small defects or stresses within integrated photonic devices.

An in-plane, three-port filter consisting of input/output waveguides and two point-defect cavities in a 2D PC slab is designed and fabricated, where a new feedback method is introduced, and its transmission properties are measured. The measured minimum output wavelength spacing between two channels is 1.5 nm, which is realized by slightly adjusting the size of the resonant cavities. The measured resonant wavelengths of two cavities agree well with the calculated ones and the quality factors of the cavities are almost the same. It is believed that this kind of filter may be useful in optical integrated circuits with high density.

Tightly confined light enables a variety of applications ranging from nonlinear light management to atomic manipulation. Photonic-crystal fibres (PCFs) can provide strong guidance in very small cores while simultaneously offering long interaction lengths1. However, light confinement in waveguides is usually ultimately limited by diffraction2,3, which tends to spread light away from the waveguiding core, despite its higher refractive index. It was recently demonstrated that such spreading fields can be trapped by a nanometre-scale slot inside a strongly guiding silicon-on-insulator (SOI) waveguide4,5.

We study the effects of metal-coated fiber near-field probes on the performance of nanophotonic devices. Employing a heterodyne near-field scanning optical microscope and analyzing transmission characteristics, we find that a metal-coated probe can typically introduce a 3 dB intensity loss and a 0.2 rad phase shift during characterization of a straight waveguide made in a silicon-on-insulator system. In resonant nanophotonic structures such as a 5
m radius microring resonator, we demonstrate that the probe induces a 1 nm shift in resonant wavelength and decreases the resonator quality factor, Q, from 1100 to 480. © 2007 Optical Society of America

Slab waveguides were constructed in K1-xLixTa1-yNbyO3 crystals by the implantation of 12C+4 ions at 30MeV, and 16O+5 ions at 30MeV and 40MeV. The waveguides were characterized by a prism coupler set-up. A refractive index drop of 10.9% was observed in a layer formed by the implantation of 16O+5 ions at 30MeV. The carbon implanted waveguides were found to be thermally stable after annealing at 450°C.

Amylose-conjugated linoleic acid (CLA) complexes were produced by water/dimethyl sulfoxide (DMSO) and KOH/HCl complexation methods. The formation of amylose V form was confirmed by X-ray diffraction (XRD), and complexes formed at 30, 60, and 90 °C exhibit melting temperatures exceeding 88 °C. Atomic force microscopy (AFM) images showed distinct difference in complex organization, with complexes formed in water/DMSO showing spherical shape with typical diameter of 150 nm. Complexes formed by KOH/ HCl showed elongated structure with typical width of 43-160 nm. Water/DMSO complexes exhibit superior protection to CLA against oxidation. All complexes showed high retention of CLA in simulated stomach conditions, and the digestion of complexes by amylases results in high hydrolysis and CLA release by pancreatin and R-amylase. Only moderate release was detected following hydrolysis by amyloglucosidase and â-amylase. It is therefore suggested that amylose-CLA complexes can serve as molecular nanocapsules for protection and delivery of CLA.

Photonic crystal sPCd or photonic band-gap material is a material that possesses a periodic modulation of refractive index. Such a material exhibits a so-called photonic band gap where certain ranges of frequencies of the electromagnetic waves cannot propagate, which is analogous to the electronic band gap in semiconductors. By tailoring the photonic band gap, light can be manipulated in a PC.

The colloidal PCs studied in this work is produced by the self-assembly of monodisperse polystyrene colloidal spheres into hemispherical colloidal aggregates of internally ordered structure. The aggregates are formed from colloidal droplets patterned on the substrate by ink-jet printing, as the solvent is rapidly removed from the droplet.20 Unlike many other techniques of patterned growth of colloidal PCs,21–24 the substrate does not need to be patterned first, and no template is needed, i.e., the droplet itself serves as the template. This technique has the potential to produce more complex patterns.

Trace detection and analysis is critical to many areas of pharmaceutical manufacturing and research, including materials identification (raw materials and products) and cleaning validation. In addition, all pharmaceutical products are developed and manufactured under the scrutiny of regulatory agencies and are, therefore, governed by strict standards in terms of both quality of product and recordkeeping. Analysis can be time-consuming, resulting in delays in production. Consequently, pharmaceutical manufacturers are constantly on the lookout for new technologies and instrumentation that can make trace detection faster and more cost efficient.

Cleaning validation tests the efficacy of cleaning methods used in pharmaceutical research and manufacturing. It is a critical and timeintensive step. Process equipment must be cleaned after every stage in the drug development process and the equipment cannot be reused until the cleaning is validated. In cleaning validation, samples are taken from the equipment and analyzed for pre-determined thresholds of probable contaminants, in particular for active pharmaceutical ingredients (APIs) from previous batches.

Introduction Clinical trials are an important part ofthe drug product development process.While the physical attributes of commercially available tablets and capsulesmay be useful for identification of drug products, the unique appearance of these dosage forms can be problematic in clinical trials, especially when the studies collect subjective data.

The need to verify cleaning between manufacturing runs presents a special challenge to the analytical chemist. In this article, the principles of ion mobility spectrometry are described, its performance is compared to HPLC for the analysis of cleaning validation samples, and findings are presented from a study to establish the feasibility of using IMS in validating a cleaning verification method.

Introduction An IMS method for determining trace quantities of Dober’s Chematic 91 detergent (an acidic detergent) has been developed using the IONSCAN-LS. The method is based on the detection of the non-ionic surfactant NPE (nonylphenol ethoxylate), a material also found in other detergents, and variations of this method can readily be developed to analyze for those detergents.

Introduction An IMS method for determining trace quantities of ND-165 detergent (a basic detergent manufactured by NCH Corp.) has been developed using the IONSCAN-LS. The method is based on the detection of the surfactant 2,6,8-trimethyl-4- nonyloxypolyoxyethanol. This surfactant is also found in other detergents, and variations of this method can readily be developed to analyze for those detergents.

Introduction An IMS method for determining trace quantities of Fuller Brush’s Formula 939 detergent (a basic detergent) has been developed using the IONSCAN-LS. The method is based on the detection of the surfactant NPE (nonylphenol ethoxylate), a material also found in other detergents, and variations of this method can readily be developed to analyze for those detergents.

Abstract Lactose can be detected and quantitatively analyzed by Ion mobility spectrometry (IMS). An LOQ of 0.00026 mg has been achieved, which make IMS a potential alternative analytical instrument for containment studies.

As new and more potentially active pharmaceutical ingredients (APIs) enter the processing pipeline, protecting workers from hazardous compounds is becoming an increasing concern in the pharmaceutical manufacturing industry. Typically between 5 and 10 percent of commercial available drugs are in the high potency catagory. This number is expected to increase to about 25 percent as more patented small-molecule APIs, currently the fastest growing segment of pharmaceutical research, reach the market.1