美国SP Virtis Ultra 小批量生产型冻干机

疫苗的冷冻干燥-在配方和工艺开发中的挑战和概念

Vaccination prevents millions of deaths from infectious diseases per year; however, there are still millions of people who die from these diseases due to weak thermostability demanding cold chains, long-term stability issues and distribution challenges. All these limitations can be overcome by creating a dry product through lyophilization. With the urgency to develop a coronavirus vaccine, it is a crucial time to discuss the process of freeze-drying vaccines.

可调谐二极管激光吸收光谱(TDLAS)在药物冻干过程监测中的应用

This technical brief provides an overview of Tunable Diode Laser Absorption Spectroscopy (TDLAS) and its application for monitoring freeze drying processes. Through the combination of TDLAS

Basic Principles Of Freeze-Drying

Freeze-drying is the removal of ice or other frozen solvents froma material through the process of sublimation and the removal ofbound water molecules through the process of desorption. Lyophilization and freeze-drying are terms that are usedinterchangeably depending on the industry and location wherethe drying is taking place. Controlled freeze-drying keeps the product temperature low enough during the process to avoidchanges in the dried product appearance and characteristics. It is an excellent method for preserving a wide variety of heat sensitive materials such as proteins, microbes, pharmaceuticals,tissues & plasma.