Q3|国内BLI文献盘点:小分子研究愈发火热

单位

数量

单位

数量

南京中医药大学

3

上海生化所

1

中国药科大学

3

中国科学院高能物理研究所

1

西湖大学

3

武汉病毒所

1

温州医科大学

2

清华大学

1

浙江中医药大学

2

南京大学

1

中国海洋大学

2

中国科学技术大学

1

中国医学科学院北京协和医学院

2

厦门大学

1

暨南大学

2

上海药物所

1

广州生物医药与健康研究院

2

中国食品药品检定研究院

1

深圳先进技术研究院

2

广州医科大学第二附属医院

1

复旦大学

2

上海宝济药业有限公司

1

浙江大学

2

南京医科大学第一附属医院

1

北京大学

2

江苏植物研究所

1

南京农业大学

1

上海迈石生物技术有限公司

1

神州细胞

1

澳门科技大学

1

上海有机所

1

集美大学

1

复旦大学静安中心医院

1

大连工业大学

1

中国中生

1

青岛大学附属医院

1

昆明医科大学第一附属医院

1

青岛海洋科学与技术国家实验室

1

民用nbc防护国家重点实验室

1

海军军医大学

1

云南农业大学

1

北京化工大学

1

东北师范大学

1

北京中医药大学

1

国家食品安全风险评估中心

1

丁浮靶点

1

上海耳鼻喉医院

1

武汉大学中南医院

1

国家纳米科学与技术中心

1

西南医科大学

1

贵州医科大学

1

南京师范大学

1

中国人民解放军总医院第一医疗中心

1

杭州医学院

1

中南民族大学

1

生物物理所

1

西北大学

1

上海交通大学

1

中国海洋大学

1

浙江工业大学

1

序号

文献题目

期刊类别

单位名称

应用领域

1

Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases

Acta Pharmaceutica Sinica BAvailable online 25 September 2022...

温州医科大学

小分子

2

Mechanism investigation of Caspase-8/GSDMC dependent immunogenic cell death induced by Ophiopogonin B in NSCLC cells

Pharmacological Research - Modern Chinese Medicine29 August 2022...

南京中医药大学

小分子

3

Fragments of bombinakinin M exist in lipopolysaccharide-stimulated skin secretions of Bombina maxima and show lipopolysaccharide-neutralizing activity

Journal of Immunological Methods25 August 2022...

昆明医科大学第一附属医院

小分子

4

Oxidized tea polyphenol (OTP-3) targets EGFR synergistic nimotuzumab at inhibition of non-small cell lung tumor growth

Bioorganic Chemistry6 August 2022...

云南农业大学

小分子

5

A preliminary cumulative risk assessment of Diethylhexyl phthalate and Dibutyl phthalate based on the inhibition of embryonic development via the PPARγ pathway

Toxicology in Vitro25 July 2022...

国家食品安全风险评估中心

小分子

6

Inhibiting STAT5 signaling pathway by natural products for cancer prevention and therapy: In vitro and in vivo activity and mechanisms of action

Pharmacological Research19 July 2024...

浙江中医药大学

小分子

7

Optimizing component formula suppresses lung cancer by blocking DTL-mediated PDCD6 ubiquitination to regulate the MAPK/JNK pathway

Journal of Ethnopharmacology15 July 2024...

南京中医药大学

小分子

8

Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies

Bioorganic Chemistry7 July 2022...

贵州医科大学

小分子

9

Discovery of Isoform-Selective Akt3 Degraders Overcoming Osimertinib-Induced Resistance in Non-Small Cell Lung Cancer Cells

Journal of Medicinal Chemistry

暨南大学

小分子

10

AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis

Nature Communications volume 13, Article number: 4499 (2022)

南京大学

小分子

11

Discovery of 2-(1-(3-Chloro-4-cyanophenyl)-1H-pyrazol-3-yl)acetamides as Potent, Selective, and Orally Available Antagonists Targeting the Androgen Receptor

J. Med. Chem. 2022

浙江大学

小分子

12

PDTAC: Targeted Photodegradation of GPX4 Triggers Ferroptosis and Potent Antitumor Immunity

J. Med. Chem. 2022, 65, 18, 12176–12187

北京大学

小分子

13

Discovery of a Highly Potent and Selective Dual PROTAC Degrader of CDK12 and CDK13

J. Med. Chem. 2022, 65, 16, 11066–11083

暨南大学

小分子

14

Selective Photoaffinity Probe for Monitoring Farnesoid X Receptor Expression in Cultured Cells

Anal. Chem. 2022, 94, 30, 10722–10729

中国药科大学

小分子

15

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation

 https://doi.org/10.1002/advs.202202590

温州医科大学

小分子

16

Substrate-induced dimerization of elaiophylin glycosyltransferase reveals a novel self-activating form of glycosyltransferase for symmetric glycosylation

Acta Crystallographica Section D

Guangzhou Institutes of Biomedicine and Health,

小分子

17

Calycosin protects against oxidative stress-induced cardiomyocyte apoptosis by activating aldehyde dehydrogenase 2

https://doi.org/10.1002/ptr.7591

the Second Affiliated Hospital of Guangzhou Medical University

小分子

18

Vegetable-derived indole enhances the melanoma-treating efficacy of chemotherapeutics

https://doi.org/10.1002/ptr.7565

南京中医药大学

小分子

19

Crucial role of Ca2+/CN signalling pathway in the antifungal activity of disenecioyl-cis-khellactone against Botrytis cinerea

https://doi.org/10.1002/ps.7085

江苏省中国科学院植物研究所

小分子

20

[Progress of target determination and mechanism of bioactive components of traditional Chinese medicine]

 Zhongguo Zhongyao Zazhi

北京中医药大学

小分子

21

Galangin Exhibits Neuroprotective Effects in 6-OHDA-Induced Models of Parkinson’s Disease via the Nrf2/Keap1 Pathway

Pharmaceuticals 2022, 15(8), 1014

西南医科大学

小分子

22

A Small-Molecule Inhibitor of the Anthranilyl-CoA Synthetase PqsA for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa

Antimicrobial Chemotherapy

浙江工业大学

小分子

23

Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia

Cell Reports20 September 2022...

中国科学院上海有机化学研究所

蛋白

24

Sequence difference of angiotensin-converting enzyme 2 between nonhuman primates affects its binding-affinity with SARS-CoV-2 S receptor binding domain

Biosafety and HealthAvailable online 9 September 2022...

中国生物技术股份有限公司

蛋白

25

The mechanisms of immune response and evasion by the main SARS-CoV-2 variants

iScience2 September 2022...

浙江中医药大学

蛋白

26

SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR

Acta Pharmaceutica Sinica BAvailable online 27 August 2022...

中国药科大学

蛋白

27

An emerging paradigm to develop analytical methods based on immobilized transmembrane proteins and its applications in drug discovery

TrAC Trends in Analytical Chemistry4 July 2022...

西北大学

蛋白

28

Metabolic pathway assembly using docking domains from type I cis-AT polyketide synthases

Nature Communications volume 13, Article number: 5541 (2022)

Shenzhen Institute of Synthetic Biology

蛋白

29

Insulin induces insulin receptor degradation in the liver through EphB4

Nature Metabolism volume 4, pages1202–1213 (2022)

Chinese Academy of Medical Sciences and Peking Union Medical College

蛋白

30

Celastrol recruits UBE3A to recognize and degrade the DNA binding domain of steroid receptors

Oncogene volume 41, pages4754–4767 (2022)

上海生物化学与细胞生物学研究所

蛋白

31

LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin

Communications Biology volume 5, Article number: 906 (2022) 

西湖大学

蛋白

32

Structural insights into partner selection for MYB and bHLH transcription factor complexes

Nature Plants volume 8, pages1108–1117 (2022

复旦大学

蛋白

33

APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients

Signal Transduction and Targeted Therapy volume 7,

厦门大学

蛋白

34

Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay

J. Chem. Inf. Model. 2022, 62, 18, 4512–4522

中国科学院上海药物研究所

蛋白

35

Insight into Thermodynamic and Kinetic Profiles in Small-Molecule Optimization

J. Med. Chem. 2022, 65, 16, 10809–10847

中国药科大学

蛋白

36

Third-Generation Covalent TMP-Tag for Fast Labeling and Multiplexed Imaging of Cellular Proteins

北京大学

蛋白

37

Structures, biomimetic synthesis, and anti-SARS-CoV-2 activity of two pairs of enantiomeric phenylpropanoid-conjugated protoberberine alkaloids from the rhizomes of Corydalis decumbens

Archives of Pharmacal Research volume 45, pages631–643 (2022)

澳门科技大学

蛋白

38

Screening and Characterization of Shark-Derived VNARs against SARS-CoV-2 Spike RBD Protein

Int. J. Mol. Sci. 2022, 23(18), 10904

集美大学

蛋白

39

The Generation of Dual-Targeting Fusion Protein PD-L1/CD47 for the Inhibition of Triple-Negative Breast Cancer

Biomedicines 2022, 10(8), 1843

上海交通大学

蛋白

40

Development of a thermostable SARS-CoV-2 variant-based bivalent protein vaccine with cross-neutralizing potency against Omicron subvariants

Virology20 September 2022...

北京义翘神州科技股份有限公司

抗体

41

SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope

Nature Microbiology volume 7, pages1635–1649 (2022)

Guangzhou Institutes of Biomedicine and Health

抗体

42

Engineering SARS-CoV-2 specific cocktail antibodies into a bispecific format improves neutralizing potency and breadth

Nature Communications volume 13, Article number: 5552 (2022)

西湖大学

抗体

43

A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery

Signal Transduction and Targeted Therapy volume 7, Article number: 301 (2022) 

中国科学院武汉病毒研究所

抗体

44

Structural insights into auxin recognition and efflux by Arabidopsis PIN1.

Nature volume 609, pages611–615 (2022)

中国科学技术大学

抗体

45

Branched Polyethylenimine as a Carrier for Significantly Improving the Biopanning Efficiency of Phages Specific to Hapten

ACS Appl. Polym. Mater. 2022, 4, 8, 5737–5745

中国海洋大学

抗体

46

Novel hKDR mouse model depicts the antiangiogenesis and apoptosis-promoting effects of neutralizing antibodies targeting vascular endothelial growth factor receptor 2

 https://doi.org/10.1111/cas.15594

National Institutes for Food and Drug Control (NIFDC)

抗体

47

Novel application of anti-human Fc nanobody for screening high-producing CHO cells for monoclonal antibody

 https://doi.org/10.1002/elsc.202200028

Shanghai Bao Pharmaceuticals Co., Ltd.,

抗体

48

Development of a variant of dinutuximab with enhanced antitumor efficacy and reduced induction of neuropathic pain

https://doi.org/10.1002/2211-5463.13464

 Shanghai Mabstone Biotechonology

抗体

49

A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode

Journal of Nanobiotechnology volume 20, Article number: 411 (2022)

The Affiliated Hospital of Qingdao University

抗体

50

Structural Basis of a Novel Agonistic Anti-OX40 Antibody.

Biomolecules 2022, 12(9), 1209

丁浮靶点

抗体

51

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer

Structural Biology

复旦大学

抗体

52

Anti-mesothelin CAR-T immunotherapy in patients with ovarian cancer

Cancer Immunology, Immunotherapy (2022)

南京师范大学

抗体

53

Aptasensing a class of small molecules based on split aptamers and hybridization chain reaction-assisted AuNPs nanozyme

Food Chemistry29 August 2022...

中国海洋大学

DNA

54

Ricin aptamer screening based on the QSAR model and construction of piezoresistive micro-cantilever aptasensor

Talanta18 August 2022...

民用nbc防护国家重点实验室

DNA

55

One-step high-throughput detection of low-abundance biomarker BDNF using a biolayer interferometry-based 7D aptasensor

Biosensors and Bioelectronics14 July 2026...

上海耳鼻喉医院

DNA

56

Biochemical and structural characterization of a KTSC family single-stranded DNA-binding protein from Euryarchaea

International Journal of Biological Macromolecules7 July 2022...

Chinese PLA General Hospital First Medical Center

DNA

57

A facile and integrated aptamer-based platform for preliminary and simultaneous screening of group targets

Sensors and Actuators B: Chemical3 July 2022...

中国海洋大学

DNA

58

A Label-Free Colorimetric Aptasensor Containing DNA Triplex Molecular Switch and AuNP Nanozyme for Highly Sensitive Detection of Saxitoxin

Journal of Ocean University of China volume 21, pages1343–1350 (2022

DNA

59

Optimization of Gonyautoxin1/4-Binding G-Quadruplex Aptamers by Label-Free Surface-Enhanced Raman Spectroscopy

Toxins 2022, 14(9), 622; https://doi.org/10.3390/toxins14090622

海军军医大学

DNA

60

Evolution of Interferon-Gamma Aptamer with Good Affinity and Analytical Utility by a Rational In Silico Base Mutagenesis Post-SELEX Strategy

Beijing University of Chemical Technology

北京化工大学

DNA

61

CDKN2AIP is critical for spermiogenesis and germ cell development

Cell & Bioscience volume 12

Zhongnan Hospital of Wuhan University

DNA

62

Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress

Communications Biology volume 5, Article number: 822 (2022)

清华大学

RNA

63

An anti-picornaviral strategy based on the crystal structure of foot-and-mouth disease virus 2C protein

Cell Reports5 July 2022...

Chinese Academy of Medical Sciences and Peking Union Medical College

多肽

64

Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression

https://doi.org/10.1002/advs.202200546

First Affiliated Hospital of Nanjing Medical University

多肽

65

BTApep-TAT peptide inhibits ADP-ribosylation of BORIS to induce DNA damage in cancer

Molecular Cancer volume 21, Article number: 158 (2022) 

杭州医学院

多肽

66

EGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association

Journal of Biological Chemistry3 August 2022...

东北师范大学

多糖

67

A Sulfated Abalone Polysaccharide Inhibited SARS-CoV-2 Infection of Vero E6 Cells In Vitro

Foods 2022, 11(18), 2865

大连工业大学

多糖

68

Research trends in biomedical applications of two-dimensional nanomaterials over the last decade – A bibliometric analysis

Advanced Drug Delivery Reviews12 July 2022...

National Center for Nanoscience and Technology

垂钓

69

In situ analysis of nanoparticle soft corona and dynamic evolution

Nature Communications volume 13, Article number: 5389 (2022)

Institute of High Energy Physics & National Center for Nanoscience and Technology of China

垂钓

70

Morphology-driven protein corona manipulation for preferential delivery of lipid nanodiscs

Nano Today11 September 2022...

上海市静安区中心医院

纳米材料

71

A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination

Nature Nanotechnology volume 17, pages993–1003 (2022)

中国科学院深圳先进技术研究院

纳米材料

72

Glucose sensing by regulator of G protein signaling 1 (RGS1) plays a crucial role in coordinating defense in response to environmental variation in tomato

 https://doi.org/10.1111/nph.18356

浙江大学

细胞

73

Simultaneous Maturation of Single Chain Antibody Stability and Affinity by CHO Cell Display

Bioengineering 2022, 9(8), 360

中科院生物物理研究所

定量

74

Re-understanding of structure and anticoagulation: Fucosylated chondroitin sulfate from sea cucumber Ludwigothurea grisea

Carbohydrate Polymers5 July 2022...

中南民族大学

蔗糖

75

Identifying the Epitopes of Bacillus thuringiensis Cry2Aa Toxin Involved in Cadherin Interaction by a Monoclonal Antibody

Applied Biochemistry and Biotechnology (2022)

南京农业大学

76

Cryo-EM structure of the human IgM B cell receptor

SCIENCE VOL. 377

西湖大学