High-throughput CD spectral measurement: biomedicines and pH dependency
简介:Biomedicine is a medicinal response to a physical or
biological issue with the human body. Biomedicines use
active ingredients derived from proteins and the research
and development behind these methods is increasing
简介:Biomedicine is a medicinal response to a physical or
biological issue with the human body. Biomedicines use
active ingredients derived from proteins and the research
and development behind these methods is increasing
daily. However, these biomedicines are more sensitive to
environmental changes, such as a change in temperature,
pH, and salt concentration, than traditional pharmaceuticals.
To meet the demand for increased sample throughput in the
modern pharmaceutical laboratory, JASCO has developed a
fully automated high-throughput CD spectral measurement
system. This system is composed of a J-1500 CD
spectrometer with an autosampler unit. The high-throughput
CD system enables the automation of sample pretreatment,
injection and washing.
In this application note, we will demonstrate the use of the ASU-800 automated system to evaluate the pH dependency
on the structure of human serum albumin (HSA)详细>