简介:The use of liquid chromatography (LC) in pesticide residue determination was usually limited to
groups of compounds or single compounds for which no suitable gas chromatographic (GC) conditions
were available. However,简介:The use of liquid chromatography (LC) in pesticide residue determination was usually limited to
groups of compounds or single compounds for which no suitable gas chromatographic (GC) conditions
were available. However, recent developments have significantly enlarged the LC scope in this field
of analysis. One of the most important advances was the on-line coupling of efficient LC separation
with mass spectrometry detectors (LC-MS and LC-MS/MS) that makes this technique an excellent
method for the determination of pesticides and their transformation products in complex matrices
such as food. This review considers the application of LC-MS/MS in this field. Emphasis is placed on
the tandemMSapplications: advantages of the technique; the sensitive and unequivocal confirmation
of the presence of pesticides in food; and, important factors affecting the performance of LC-MS/MS
instruments, like the type of mass analyzer or the ionization source design which would be discussed
on the particular framework of pesticide and their metabolite analysis. This review also highlights a
number of problems associated with the LC-MS/MS analysis of pesticides such as the matrix effects
that make quantification difficult.详细>