简介:磷酸化腺苷单磷酸活化蛋白激酶α2抗体
Background: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non简介:磷酸化腺苷单磷酸活化蛋白激酶α2抗体
Background: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008] Also known as: AMPK alpha 2 (phospho Ser345); AMPK alpha 2 (phospho S345); p-AMPK alpha 2 (S345); p-AMPK alpha 2 (Ser345); p-AMPK2(phospho S345); 5'-AMP-activated protein kinase catalytic subunit alpha-2; AAPK2_HUMAN; AMP activated protein kinase alpha 2 catalytic subunit; AMPK 2; AMPK alpha 2 chain; AMPK subunit alpha-2; ; AMPKalpha2; PRKAA 2; PRKAA; PRKAA2; Protein kinase AMP activated alpha 2 catalytic subunit.磷酸化腺苷单磷酸活化蛋白激酶α2抗体
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